Malignant neoplasm of mouth
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We used immunohistochemical and molecular genetic techniques to investigate whether p53 alterations at the invasive tumor front could determine the aggressiveness of oral cancers.
|
9464946 |
1998 |
Malignant neoplasm of mouth
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Here, we identified a relatively rare mutation leading to a proline to leucine substitution (P152L) in TP53 at the very end of its DNA-binding domain (DBD) in a sample from an Indian oral cancer patient.
|
31366730 |
2019 |
Malignant neoplasm of mouth
|
0.600 |
Biomarker
|
group |
BEFREE |
The unexplained survival of cells in oral cancer: what is the role of p53?
|
11903817 |
2002 |
Malignant neoplasm of mouth
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Mapping of resection margins of oral cancer for p53 overexpression and chromosome instability to detect residual (pre)malignant cells.
|
11169517 |
2001 |
Malignant neoplasm of mouth
|
0.600 |
Biomarker
|
group |
BEFREE |
Randomized, controlled phase II study of post-surgery radiotherapy combined with recombinant adenoviral human p53 gene therapy in treatment of oral cancer.
|
23722592 |
2013 |
Malignant neoplasm of mouth
|
0.600 |
GeneticVariation
|
group |
BEFREE |
BQ chewing was shown to be associated with p53 mutation in oral cancers.
|
16271069 |
2005 |
Malignant neoplasm of mouth
|
0.600 |
GeneticVariation
|
group |
BEFREE |
As a result, the proposed PEC biosensor showed excellent analytical performance for both oral cancer (ORVOA 1) gene and p53 gene down to attomolar level.
|
27003607 |
2016 |
Malignant neoplasm of mouth
|
0.600 |
GeneticVariation
|
group |
BEFREE |
While the results suggest that the P53 codon 72 polymorphism may contribute to oral cancer susceptibility, larger studies are needed to confirm these findings.
|
12065086 |
2002 |
Malignant neoplasm of mouth
|
0.600 |
Biomarker
|
group |
BEFREE |
In this study, we focused on p53 mutations in specific regions, including DNA-binding surface regions, to clarify the correlation between mutations within the specific regions of p53 and clinical outcomes of patients with oral cancers.
|
12509970 |
2003 |
Malignant neoplasm of mouth
|
0.600 |
AlteredExpression
|
group |
BEFREE |
A significant influence on the survival of stage III patients was also found for the combinations of p21 and p27 proteins with p21+/p27- imparting the best and p21-/p27+ the worst prognosis (P = 0.04). p27 expression was significantly related to oral cancer specimens (P = 0.04) and to moderate and high tumor grade (P = 0.01). p53 expression was not significantly related to any of the examined clinicopathological characteristics.
|
11299798 |
2001 |
Malignant neoplasm of mouth
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Alterations in p53 tumour suppressor gene and its expression may be implicated in the pathogenesis of betel- and tobacco-related oral cancer.
|
11287278 |
2001 |
Malignant neoplasm of mouth
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in Argentine patients.
|
28459200 |
2017 |
Malignant neoplasm of mouth
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The present data indicate that p53 mutations are extremely frequent in oral cancers in the Japanese, and suggest that the timing and significance of p53 mutation in oral tumor progression vary in different ethnic populations and areas.
|
9400993 |
1997 |
Malignant neoplasm of mouth
|
0.600 |
PosttranslationalModification
|
group |
BEFREE |
These results indicate that inactivation of p53 gene is associated with development and/or progression of oral cancer.
|
10621851 |
1999 |
Malignant neoplasm of mouth
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Identification and characterization of TP53 gene Allele Dropout in Li-Fraumeni syndrome and Oral cancer cohorts.
|
30076369 |
2018 |
Malignant neoplasm of mouth
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Our previous work showed that acquisition of immortality at the dysplasia stage of oral cancer progression was consistently associated with four changes: loss of retinoic acid receptor (RAR)-beta and p16INK4A expression, p53 mutations and activation of telomerase.
|
14586406 |
2003 |
Malignant neoplasm of mouth
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Our data showed that curcumin treatment not only decreased the expression of MMP-2 and MMP-9 to inhibit invasiveness in oral cancer but also modulated the expression of EMT markers, such as Snail, Twist, and E-cadherin, and induced p53 expression that is crucial to EMT repression.
|
26036622 |
2015 |
Malignant neoplasm of mouth
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The unexpected finding of p53 protein in clinically healthy mucosa was confined to subjects aged over 40 years who smoked tobacco, a known risk factor for oral cancer.
|
8670041 |
1996 |
Malignant neoplasm of mouth
|
0.600 |
Biomarker
|
group |
BEFREE |
In contrast, LOH at 3p14 (<i>P </i>= 0.0241), 17p13 (<i>P </i>= 0.0348) and TP53 (<i>P </i>= 0.004) were associated with oral cancer development in the classical subtype only.
|
30524889 |
2018 |
Malignant neoplasm of mouth
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Establishment of human oral-cancer cell lines (KOSC-2 and -3) carrying p53 and c-myc abnormalities by geneticin treatment.
|
8314315 |
1994 |
Malignant neoplasm of mouth
|
0.600 |
Biomarker
|
group |
BEFREE |
Evaluation of p53 protein as a prognostic factor for oral cancer surgery.
|
23791033 |
2013 |
Malignant neoplasm of mouth
|
0.600 |
Biomarker
|
group |
BEFREE |
The overall p53 alterations in oral cancer tissues and oral lesions are comparable to data from the oral cancers reported in the Western countries with smoking and alcohol-associated oral cancers, and suggest a critical role for p53 gene in a significant proportion of oral cancers from India.
|
10621843 |
1999 |
Malignant neoplasm of mouth
|
0.600 |
Biomarker
|
group |
BEFREE |
Expression of the tumour suppressor gene p53 in oral cancer.
|
1380822 |
1992 |
Malignant neoplasm of mouth
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Neither overall analysis nor stratified analyses detected any obvious evidence of association between p53 Arg72Pro polymorphism and oral cancer susceptibility in all genetic models.
|
26123760 |
2015 |
Malignant neoplasm of mouth
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Both pRB/p16(INK4A) and p53 are dysfunctional in many cancers, including the most common type of oral cancer, squamous cell carcinoma (OSCC) and other evidence is accumulating in support of the idea that senescence acts as a barrier to tumour development and/or progression.
|
21050803 |
2010 |