Malignant neoplasm of mouth
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Here, we identified a relatively rare mutation leading to a proline to leucine substitution (P152L) in TP53 at the very end of its DNA-binding domain (DBD) in a sample from an Indian oral cancer patient.
|
31366730 |
2019 |
Malignant neoplasm of mouth
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Identification and characterization of TP53 gene Allele Dropout in Li-Fraumeni syndrome and Oral cancer cohorts.
|
30076369 |
2018 |
Malignant neoplasm of mouth
|
0.600 |
Biomarker
|
group |
BEFREE |
In contrast, LOH at 3p14 (<i>P </i>= 0.0241), 17p13 (<i>P </i>= 0.0348) and TP53 (<i>P </i>= 0.004) were associated with oral cancer development in the classical subtype only.
|
30524889 |
2018 |
Malignant neoplasm of mouth
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Sensory acceptable equivalent doses of β-phenylethyl isothiocyanate (PEITC) induce cell cycle arrest and retard the growth of p53 mutated oral cancer in vitro and in vivo.
|
29923573 |
2018 |
Malignant neoplasm of mouth
|
0.600 |
Biomarker
|
group |
BEFREE |
Metallic gold and bioactive quinacrine hybrid nanoparticles inhibit oral cancer stem cell and angiogenesis by deregulating inflammatory cytokines in p53 dependent manner.
|
29366881 |
2018 |
Malignant neoplasm of mouth
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Meta-Analysis Results on the Association Between TP53 Codon 72 Polymorphism With the Susceptibility to Oral Cancer.
|
30116199 |
2018 |
Malignant neoplasm of mouth
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in Argentine patients.
|
28459200 |
2017 |
Malignant neoplasm of mouth
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The combination of vorinostat and AZD1775 inhibits tumor growth and angiogenesis <i>in vivo</i> in an orthotopic mouse model of oral cancer and prolongs animal survival.<b>Conclusions:</b> Vorinostat synergizes with AZD1775 in HNSCC cells with mutant p53 <i>in vitro</i> and <i>in vivo</i> A strategy combining HDAC and WEE1 inhibition deserves further clinical investigation in patients with advanced HNSCC.<i></i>.
|
28790110 |
2017 |
Malignant neoplasm of mouth
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Gender specific association of TP53 polymorphisms (EX4 215G>C Arg72Pro, IVS3+40-41ins16, and IVS6+62G>A), with risk of oral cancer subtypes and overall survival of the patients.
|
27532290 |
2017 |
Malignant neoplasm of mouth
|
0.600 |
GeneticVariation
|
group |
BEFREE |
In oral cancer p53 is mutated, thus we focused on p73; AGG resulted in p73 upregulation and knock down of p73 caused a decrease in AGG-induced apoptosis.
|
28543759 |
2017 |
Malignant neoplasm of mouth
|
0.600 |
GeneticVariation
|
group |
BEFREE |
As a result, the proposed PEC biosensor showed excellent analytical performance for both oral cancer (ORVOA 1) gene and p53 gene down to attomolar level.
|
27003607 |
2016 |
Malignant neoplasm of mouth
|
0.600 |
Biomarker
|
group |
BEFREE |
To identify the prognostic value of c-jun, c-fos, and p53 in oral cancer, we examined the impact of immunohistochemical expression of these markers on tumor progression in 157 oral squamous cell carcinoma (OSCC).
|
27558649 |
2016 |
Malignant neoplasm of mouth
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Our data showed that curcumin treatment not only decreased the expression of MMP-2 and MMP-9 to inhibit invasiveness in oral cancer but also modulated the expression of EMT markers, such as Snail, Twist, and E-cadherin, and induced p53 expression that is crucial to EMT repression.
|
26036622 |
2015 |
Malignant neoplasm of mouth
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Neither overall analysis nor stratified analyses detected any obvious evidence of association between p53 Arg72Pro polymorphism and oral cancer susceptibility in all genetic models.
|
26123760 |
2015 |
Malignant neoplasm of mouth
|
0.600 |
Biomarker
|
group |
BEFREE |
The detection limits, established as 3σ, were estimated to be 0.03 and 0.06 fmol L(-1) for the p53 and oral cancer genes, respectively.
|
25493424 |
2015 |
Malignant neoplasm of mouth
|
0.600 |
Biomarker
|
group |
BEFREE |
The aim of the present study was to evaluate the relationship between primary oral cancer and lymph node metastasis in a series of patients with synchronous and metachronous metastases by 2 clonality tests: mt-DNA and TP53 sequence analysis.
|
25530302 |
2015 |
Malignant neoplasm of mouth
|
0.600 |
AlteredExpression
|
group |
BEFREE |
The study aims to evaluate the expression and activity of glycogen synthase kinase 3 isoforms α/β (GSK3α/β) and to assess their oncogenic potential through a correlation with the expression of cyclin D1 and p53 in oral cancer.
|
25645517 |
2015 |
Malignant neoplasm of mouth
|
0.600 |
Biomarker
|
group |
BEFREE |
Randomized, controlled phase II study of post-surgery radiotherapy combined with recombinant adenoviral human p53 gene therapy in treatment of oral cancer.
|
23722592 |
2013 |
Malignant neoplasm of mouth
|
0.600 |
Biomarker
|
group |
BEFREE |
Evaluation of p53 protein as a prognostic factor for oral cancer surgery.
|
23791033 |
2013 |
Malignant neoplasm of mouth
|
0.600 |
Biomarker
|
group |
BEFREE |
Mutated TP53 and LOH at 9p in the biopsy, as single markers and in combination, were significant risk factors for malignant progression of leukoplakia to oral cancer (Kaplan-Meier analysis, p<0.05).
|
24120275 |
2013 |
Malignant neoplasm of mouth
|
0.600 |
GeneticVariation
|
group |
BEFREE |
A high percentage of TP53 mutations were observed in OC (30%) and OPMD (average 20%) lesions (p=0.000).
|
23722122 |
2013 |
Malignant neoplasm of mouth
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Therefore, the present study evaluated the role of these p53 polymorphisms in oral cancer susceptibility in a population from Gujarat, West India.
|
23621193 |
2013 |
Malignant neoplasm of mouth
|
0.600 |
Biomarker
|
group |
BEFREE |
These results could justify more extensive research to assess p53 and HER-2/neu gene status as significant prognostic factors in oral cancers.
|
24399009 |
2013 |
Malignant neoplasm of mouth
|
0.600 |
Biomarker
|
group |
CTD_human |
Common oncogenic mutations are infrequent in oral squamous cell carcinoma of Asian origin.
|
24224046 |
2013 |
Malignant neoplasm of mouth
|
0.600 |
AlteredExpression
|
group |
BEFREE |
We earlier observed altered expression of p53 and Bcl-xL in oral cancer cell lines/tissues and wanted to evaluate these proteins for prediction of radiotherapy response and outcome.
|
22987535 |
2013 |