Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In addition, TP53 mutations in Korean patients with lung cancers have not been investigated.
|
20436704 |
2010 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Because the p53 molecular mutation involved in tumorigenesis of patients with lung cancer in Taiwan remains poorly defined, the aim of this study was to assess the p53 mutation spectrum and possible etiological factors of Taiwan's patients with Non-Small Cell Lung Cancer (NSCLC).
|
15863268 |
2005 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We evaluated 23 single nucleotide polymorphisms (SNPs) in the five nicotinic receptor related genes (CHRNB3, CHRNA6, and CHRNA5/A3/B4) previously reported to be associated with lung cancer risk and smoking behavior and 14 SNPs in the four 'control' genes (TERT, CLPTM1L, CYP1A1, and TP53), which were not reported in the smoking GWA studies.
|
25233467 |
2014 |
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
A member of the p53 family, p73 may play an important role in the development of lung cancer.
|
17136456 |
2006 |
Malignant neoplasm of lung
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Here, we show that a new lung-targeting nanoparticle is capable of delivering miRNA mimics and siRNAs to lung adenocarcinoma cells in vitro and to tumors in a genetically engineered mouse model of lung cancer based on activation of oncogenic Kirsten rat sarcoma viral oncogene homolog (Kras) and loss of p53 function.
|
25114235 |
2014 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The mutation profiles of p53 and K-ras genes in pancreatic cancer resemble that in bladder cancer rather than that in lung cancer.
|
11561602 |
2002 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We observed an increased risk of a variety of histological types of lung cancer in the carriers of the p53 germline mutation.
|
12802680 |
2003 |
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
In vivo, adenovirus-mediated gene transfer of p53-46F enhanced apoptosis, thus suppressing tumor growth of a lung cancer cell line more effectively than wild-type p53 or p53-121F, another p53 mutant.
|
16827804 |
2006 |
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
These results demonstrate a previously unrecognized relationship between p53 and REV3L in cancer cell metabolism and may lead to improvements in chemotherapy treatment plans that reduce cisplatin resistance in lung cancer.
|
29307819 |
2018 |
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
The influence of the surface chemistry of silver nanoparticles (AgNPs) on p53 mediated cell death was evaluated using human dermal fibroblast (HDF) and lung cancer (A549) cells.
|
22922335 |
2012 |
Malignant neoplasm of lung
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
No other statistically significant differences were determined in the plasma p53 protein level between patients diagnosed with lung cancer exposed and not exposed to radon.
|
29805621 |
2018 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
On the basis of the novel findings presented in this study, we modified the original serological analysis of antigens by recombinant cDNA expression cloning design in a patient with lung cancer who expressed unusually favorable clinical evolution and analyzed humoral immunity against identified mutated p53 antigen.
|
11912150 |
2002 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The imbalance between the long and short arms of chromosome 3 was determined in 24 cases of non-small-cell and small-cell lung cancers in which only small snap-frozen sections were used, allowing other simultaneous molecular analyses, such as TP53 gene mutation detection.
|
15507848 |
2004 |
Malignant neoplasm of lung
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Prognostic significance of cyclin D1 and retinoblastoma expression in combination with p53 abnormalities in primary, resected non-small cell lung cancers.
|
9815783 |
1997 |
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
This review will focus on the role of p53 and cancer susceptibility genes in the molecular pathogenesis and epidemiology of human lung cancer.
|
10341702 |
1999 |
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
The ability of this adenovirus construct (Ad-CMV-p53) to express p53 protein was examined by Western blot analysis in the H358 lung cancer cell line, which has a homozygous deletion of the p53 gene.
|
7590467 |
1995 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
To determine the association between expression of TRAIL-R2 and p53 mutation status in lung cancers, we compared the two events in 20 small-cell lung cancer (SCLC) cell lines, 20 NSCLC cell lines, and 30 primary NSCLC tumors.
|
11205299 |
2001 |
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
This report shows that much of the 682-gene signature of this murine skin carcinoma transcriptome is also present in breast and lung cancer mouse models in which p53 is inhibited.
|
22880004 |
2012 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Association between p53 codon 72 genetic polymorphism and tobacco use and lung cancer risk.
|
19129997 |
2009 |
Malignant neoplasm of lung
|
0.800 |
Biomarker
|
disease |
BEFREE |
A retroviral vector-mediated system was established to allow efficient transduction of the wild-type p53 gene into human lung cancer cell lines H358a (deleted p53) and H322a (mutant p53).
|
8280799 |
1993 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Three of 23 mutations were nonsense mutations; to date, nonsense mutations of p53 have not been reported in lung cancer.
|
1312896 |
1992 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in LC were 37.0%, 46.2%, and 16.7%, respectively; frequencies in the controls were 43.2%, 45.6%, and 11.2%, respectively (p<0.01).
|
21316118 |
2011 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
More than 50% of lung cancers (90/164) contained p53 mutations and 75% showed the combined alteration of the p53 gene and protein accumulation.
|
10424749 |
1999 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Thus, mutant p53 genes have been found in urine from patients with bladder cancer, mutant ras genes in stools from patients with colorectal and pancreatic cancers, and both mutant p53 and ras genes in sputum from patients with lung cancer.
|
7586509 |
1995 |
Malignant neoplasm of lung
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The results of this study suggest that the p53 MspI polymorphism may modify the susceptibility to lung cancer as a single factor rather than in combination with BstUI polymorphism.
|
11165394 |
2001 |