Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Co-Altered Ras/B-raf and TP53 is Associated with Extremes of Survivorship and Distinct Patterns of Metastasis in Metastatic Colorectal Cancer Patients.
|
31719050 |
2020 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Immunohistochemistry was performed for AR, ERβ and p53 on 125 primary TNBCs with known metastasis and correlated with clinicopathological parameters and outcome.
|
31563883 |
2020 |
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
KRAS and GNAS are frequently altered in low-grade AMTs, while TP53 is frequently altered in high-grade AMTs, with no apparent change in expression between primary and metastatic tumors.
|
31583543 |
2020 |
Neoplasm Metastasis
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
It has been recently shown that mutant p53 proteins mediate metabolic changes thereby promoting cancer development and metastases.
|
31112799 |
2020 |
Neoplasm Metastasis
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
Mutations in p53 have been implicated in the pathogenesis of primary prostate cancer (PCa), and are often detected in recurrent and metastatic disease.
|
31471556 |
2020 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
In addition, the knockdown of p53 in K1 and TPC-1 cells partially reversed the inhibitory effect of LINC00673 deficiency on the proliferation and metastasis of PTC cells.
|
30915752 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Ectopic expression of ZCCHC10 in lung cancer cells harboring wild-type p53 dramatically suppresses cell proliferation, colony formation, migration, invasion and cisplatin resistance in vitro, as well as tumor growth and metastasis in vivo.
|
31138778 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Thus, the p53 pathway may facilitate the development of biomarkers and therapeutic approaches to treat gastric cancer metastases to the liver.
|
30703342 |
2019 |
Neoplasm Metastasis
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
Tumors with TP53 mutations or with TP53 and TERT promoter mutations were almost always classified as high risk, and the patients developed metastases and/or died of disease.
|
31529158 |
2019 |
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Further studies found that the high CRYAB and p53 co-expression was also significantly correlated with pathological grade (<i>P</i>=0.024), lymph node metastasis (<i>P</i>=0.000), Distant metastasis (<i>P</i>=0.015), TNM stage (<i>P</i>=0.013), and survival (<i>P</i>=0.000).
|
31152111 |
2019 |
Neoplasm Metastasis
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
DHPS-dependent hypusination of eIF5A1/2 is necessary for TGFβ/fibronectin-induced breast cancer metastasis and associates with prognostically unfavorable genomic alterations in TP53.
|
31558321 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
This review has discussed the multiple functions of p53 in health, diseases, and nature evolution, summarized the frequently mutant sites of p53, and the mechanisms of Mut-p53-mediated metastasis and immune evasion in endocrine cancers.
|
30915036 |
2019 |
Neoplasm Metastasis
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
Expression of CTSL was markedly increased in human NSCLC tissues with mutant p53 (mut-p53), and p53 mutation positively correlated with metastasis of NSCLC patients.
|
30732622 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, 5-FU combined with LEP-2a also resulted in p53 activation and NF-κB inhibition, and cell cycle arrest in the S phase as well as cell metastasis stagnation.
|
30770552 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Restoration of p53 function is therefore a promising drug-targeted strategy for suppressing TNBC metastasis.
|
31534364 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Missense mutations in the <i>TP53</i> gene produce mutant p53 (mutp53) proteins which may acquire oncogenic properties favoring chemoresistance, cell migration, and metastasis.
|
30745455 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis.
|
31367040 |
2019 |
Neoplasm Metastasis
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
The objective of the study was to check whether a polymorphism in the RAD51 gene (135 G>C), Ku70 protein expression, and tumor microenvironment: proliferation rate measured by BrdUrdLI and Ki-67LI, hypoxia (glucose transporter-1 expression), P53 protein expression, and DNA ploidy can influence DNA repair capacity, the factors contributing to patient overall survival (OS) and the incidence of recurrences and metastases.
|
30289394 |
2019 |
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Our study suggests that LKB1 expression is reduced in GC, negatively correlated with p53 and survivin expression, and plays an important role in predicting invasion and metastasis of GC.
|
30863111 |
2019 |
Neoplasm Metastasis
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
KRAS, PIK3CA and TP53 mutations were associated with distant metastases and a poor prognosis.
|
30867754 |
2019 |
Neoplasm Metastasis
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
Whereas the prevalent notion is that the acquisition of the p53 GOF phenotype translates into poorer prognosis for the patient, the analysis of a human somatic p53 mutations dataset demonstrated earlier tumor onset, but decreased frequency and altered location of metastases in patients with the p53‑R248Q allele.
|
30968154 |
2019 |
Neoplasm Metastasis
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
We present the case of a 28-year-old man with an IDH1 and TP53 mutant high grade glioma with abnormalities in chromosomes 1 and 19 suggestive of anaplastic oligodendroglioma that rapidly progressed to widespread metastatic disease.
|
30738431 |
2019 |
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
EZH2 augmented p53 GOF mutant-mediated cancer growth and metastasis by increasing protein levels of mutant p53.
|
30723117 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
While PTEN inactivation leads to PC, it is not sufficient for metastasis, the loss of PTEN concurrently with the inactivation of both TP53 and RB1 empower lineage plasticity in PC cells, which substantially promotes PC metastasis and the conversion to PC adenocarcinoma to neuroendocrine PC (NEPC), demonstrating the essential function of TP53 and RB1 in the suppression of PCSCs.
|
30934773 |
2019 |
Neoplasm Metastasis
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
Combined RB family inactivation and Tp53 mutation in Pax8 + FTE caused Serous Tubal Intraepithelial Carcinoma (STIC), which metastasized rapidly to the ovarian surface.
|
31772167 |
2019 |