TP53, tumor protein p53, 7157

N. diseases: 2494; N. variants: 527
Disease: polyps ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0032584
Disease: polyps
polyps 		0.100 AlteredExpression phenotype BEFREE Associations were observed between (a) p53 wild type status and upregulation of some TP73 variants; (b) overexpression of E2F-1 and some TP73 forms; and (c) upregulation of DeltaTAp73 variants and advanced pathologic stage, lymph node metastasis, vascular invasion, presence of polyps, and tumor localization. 16380414 2006
CUI: C0032584
Disease: polyps
polyps 		0.100 AlteredExpression phenotype BEFREE Multivariate analysis showed that previous history of a polyp (P = 0.03) was inversely associated with p53 overexpression. 16896030 2006
CUI: C0032584
Disease: polyps
polyps 		0.100 Biomarker phenotype BEFREE Defects in MIB-1 proliferation indices and p53 were not significantly different among the same epithelial components in each of the polyp groups. 15712188 2005
CUI: C0032584
Disease: polyps
polyps 		0.100 Biomarker phenotype BEFREE Immunohistochemical patterns of p53 and beta catenin were studied using the natural carcinogenetic model of malignant colorectal sporadic adenoma in 27 formalin-fixed paraffin-embedded polyps. 12871177 2003
CUI: C0032584
Disease: polyps
polyps 		0.100 Biomarker phenotype BEFREE Although p53 positivity and aneuploidy were correlated with invasiveness of carcinoma in the index polyp (P = 0.025), Adnab-9 positivity was not. 12645814 2003
CUI: C0032584
Disease: polyps
polyps 		0.100 GeneticVariation phenotype BEFREE Additional and new K-ras mutations were also induced in two polyps in which K-ras mutation had pre-existed. p53 mutations were not observed in both MNNG-treated and untreated groups. 12048157 2002
CUI: C0032584
Disease: polyps
polyps 		0.100 GeneticVariation phenotype BEFREE In this study, we retrospectively evaluated whether telomerase activity and p53 gene mutations are useful parameters for detecting malignant changes in polyps in patients with FAP. 11268463 2001
CUI: C0032584
Disease: polyps
polyps 		0.100 AlteredExpression phenotype BEFREE LOH at 17p was not seen in polyps or carcinomas; immunohistochemistry showed expression of p53 in one carcinoma and focal expression in three polyps. 11215281 2001
CUI: C0032584
Disease: polyps
polyps 		0.100 GeneticVariation phenotype BEFREE We detected p53 mutations in the primary polyp, even in the cut end of the polyp. 11480796 2001
CUI: C0032584
Disease: polyps
polyps 		0.100 AlteredExpression phenotype BEFREE Hyper-plastic polyp showed an increased p21 and p53 expression with no bcl2 expression. 9651943 1998
CUI: C0032584
Disease: polyps
polyps 		0.100 GeneticVariation phenotype BEFREE A low rate of p53 mutations was detected in HCL and polyps. 9628350 1998
CUI: C0032584
Disease: polyps
polyps 		0.100 AlteredExpression phenotype BEFREE DNA sequence alterations in p53 were not found, although high p53 protein levels could be shown by immunohistochemistry in areas of carcinoma within the largest polyp. 9024310 1997
CUI: C0032584
Disease: polyps
polyps 		0.100 GeneticVariation phenotype BEFREE Patient sex, polyp location, size, degree of atypia, or p53 mutation did not affect the response, but polyps in older patients were more sensitive to sulindac. 9135523 1997
CUI: C0032584
Disease: polyps
polyps 		0.100 AlteredExpression phenotype BEFREE Weak p53 expression was demonstrated by 11.7% of the flat hyperplastic polyps but none of the exophytic polyps reacted. 7559739 1995
CUI: C0032584
Disease: polyps
polyps 		0.100 GeneticVariation phenotype BEFREE The presence of both p53 overexpression and K-ras mutation in a benign tubulovillous polyp in the present series suggests that in vivo this combination of events is insufficient to cause malignant transformation of a large bowel adenoma. 8504962 1993