Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, we demonstrated that inhibition of viral infection by p53 was mediated via p53-dependent IFN signaling, leading to IFN-stimulated response element (ISRE) activation, as well as the upregulation of IFN-stimulated genes (ISGs) and IFN-β released from infected cells.
|
30784764 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, p53 might as a highly interconnected regulator in IFN-α antiviral response and cleaved Mdm2 might as a dominant-negative regulator by competing with full length Mdm2 for p53 binding in virus infection.
|
30170033 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, we show that p53 stabilization reduces virus infection in human macrophages, highlighting the important role of p53 in antiviral immunity.
|
30674627 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Together, our results identify, for the first time, FUBP1 as a novel E1A binding protein that participates in aspects of viral replication and is involved in the E1A-mediated suppression of p53 function.<b>IMPORTANCE</b> Viral infection triggers innate cellular defense mechanisms that have evolved to block virus replication.
|
29743362 |
2018 |
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This study also provides links between the DNA damage response, the regulation of E6 PBM function, and the inhibition of p53 activity and begins to explain how HPV-infected cells remain within the cell cycle, despite activation of DNA damage response pathways during productive virus infections.<b>IMPORTANCE</b> The cancer-causing HPV E6 oncoproteins all possess a PDZ binding motif at their extreme carboxy termini.
|
29848585 |
2018 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
This study uncovers the mechanism underlying the herpesvirus-triggered apoptosis of remote host cells and extends our understanding of both herpesvirus-host interactions and the roles of p53 in viral infection.<b>IMPORTANCE</b> It is well accepted that herpesviruses suppress the apoptosis of host cells via various strategies to ensure sustained viral replication during infection.
|
29950417 |
2018 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
M. catarrhalis reduces antiviral defense functions of bronchial epithelial cells, which may increase susceptibility to viral infections.-Heinrich, A., Haarmann, H., Zahradnik, S., Frenzel, K., Schreiber, F., Klassert, T. E., Heyl, K. A., Endres, A.-S., Schmidtke, M., Hofmann, J., Slevogt, H. Moraxella catarrhalis decreases antiviral innate immune responses by down-regulation of TLR3 via inhibition of p53 in human bronchial epithelial cells.
|
26979086 |
2016 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we discuss the emerging roles of p53 and other tumour-suppressor genes in tumour immunology, as well as in additional immunological settings, such as virus infection.
|
27667712 |
2016 |
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Recombinant Newcastle disease virus expressing P53 demonstrates promising antitumor efficiency in hepatoma model.
|
27465066 |
2016 |
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
CK-19+ specific deletion of p53/Rb verified that carcinomas at the injury site originates from cholangiocytes or liver progenitor cells.These findings suggest that human liver patients with hepatitis B and C viral infection or with mutations for p53 and Rb are at high risk to develop tumors at the surgical intervention site.
|
27323406 |
2016 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Evaluation of CTNNB1 and TP53 variability in patients with hepatocellular carcinoma and occult hepatitis B virus infection.
|
26341700 |
2015 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
To address the unmet need, we recently developed RapidCaP mice, which endogenously recreate human PTEN-mutant metastatic CaP based on Cre/Luciferase expressing viral infection, that is guided to Pten(loxP)/Trp53(loxP) prostate.
|
25592467 |
2015 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
More than thirty years elapsed since a protein, not yet called p53 at the time, was detected to bind SV40 during viral infection.
|
24287312 |
2014 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, significant correlation was found between multiple viral infection (JCV, and/or SV40, and/or MMTV-like in the same tumor) and "triple negative" phenotype (P = 0.001) and also with p53 accumulation (P = 0.028).
|
22108781 |
2012 |
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of SIRT1 showed significant correlation with gender (p=0.023), serum AFP levels (p=0.030), viral infection (p=0.005) and p53 expression (p<0.021).
|
21567102 |
2011 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Present study aimed at evaluation of cellular expression of p53 protein, genetic TP53 changes in liver samples and anti-p53 in serum of patients with chronic hepatitis C virus infection.
|
19419935 |
2009 |
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Finally, H1299 (p53(-/-)) cell viability was significantly inhibited by adeno-GFP-Sp1 virus infection in the expression of p53.
|
19588484 |
2009 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
There was no association between virus infection and TP53 nuclear accumulation (p = 0.5).
|
17721920 |
2007 |
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Activation of p53 could impair a productive viral infection at many levels, including the inhibition of viral DNA replication and/or the premature death of infected cells.
|
15738654 |
2005 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The irreversible cell cycle arrest and apoptosis induced by p53 are part of the host surveillance mechanisms for viral infection and tumor induction.
|
11462029 |
2001 |
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Further analyses showed that p21(WAF1/CIP1) expression was inversely correlated with p53 expression in hepatitis C virus (HCV)-related HCCs, but not in HBV-related hepatocellular carcinomas and hepatocellular carcinomas without viral infection.
|
10883667 |
2000 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Occult hepatitis B virus infection in HBs antigen-negative hepatocellular carcinoma in a Japanese population: involvement of HBx and p53.
|
11002243 |
2000 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Cellular checkpoints that can function as 'alarm bells' to transmit pro-apoptotic signals in response to virus infections include death receptors, protein kinase R, mitochondrial membrane potential, p53 and the endoplasmic reticulum.
|
10217831 |
1999 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The incidence of p53 gene abnormalities in human hepatocellular carcinoma (HCC) varies in different geographical areas, being higher in regions where hepatitis virus infection and dietary exposure to aflatoxin B1 are the most common aetiological agents.
|
10394883 |
1999 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
This is the first report of a potential biological function for this polypeptide and may represent a means by which HPV is able to modulate the activity of the full-length E6 protein with respect to p53 during viral infection.
|
9233760 |
1997 |