T-Cell Lymphoma
|
0.600 |
Biomarker
|
disease |
CTD_mouse |
Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma.
|
29438700 |
2018 |
T-Cell Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
TP53 (p53) is a tumor suppressor whose functions are lost or altered in most malignancies. p53 homozygous knockout (p53<sup>-/-</sup>) mice uniformly die of spontaneous malignancy, typically T-cell lymphoma.
|
29572430 |
2018 |
T-Cell Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Deletion of <i>Mdm2</i> in T-cell lymphomas or sarcomas lacking p53 induced apoptosis and G<sub>2</sub> cell-cycle arrest, prolonging survival of mice with these tumors.
|
28576884 |
2017 |
T-Cell Lymphoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma.
|
26192917 |
2015 |
T-Cell Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our results provide evidence that ellipticine-induced apoptosis is exerted through DNA damage and does not require p53 activation in T-cell lymphoma.
|
24898668 |
2015 |
T-Cell Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No p53 gene mutation was detected on the exon 4 - 9, and Pro/Arg SNPs on p53 codon 72 were detected in the cutaneous NK/T-cell lymphoma.
|
23557559 |
2013 |
T-Cell Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Epstein-Barr virus-encoded miR-BART20-5p inhibits T-bet translation with secondary suppression of p53 in invasive nasal NK/T-cell lymphoma.
|
23608226 |
2013 |
T-Cell Lymphoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Cox regression test showed that p53 expression rate and international prognostic index score were statistically independent prognostic factors for NKTCL patients (p=0.002 and p=0.016, respectively).
|
23626008 |
2013 |
T-Cell Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thymic T cell lymphoma is the most common malignancy in p53-deficient mice, making it difficult to study the role of p53 in other malignancies.
|
23166633 |
2012 |
T-Cell Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Finally, irradiated mice reconstituted with p53 null, but not wild-type, HSPCs expressing Fbxo7 showed a statistically significant increase in the incidence of T cell lymphoma in vivo.
|
21695055 |
2011 |
T-Cell Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our results indicate that reduced levels of Separase act synergistically with loss of p53 in the initiation and progression of B- and T- cell lymphomas, which is aided by increased chromosomal missegregation and accumulation of genomic instability.
|
21799785 |
2011 |
T-Cell Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Expression of the multidrug resistance protein MRP and the lung-resistance protein LRP in nasal NK/T cell lymphoma: further exploring the role of P53 and WT1 gene.
|
18972317 |
2009 |
T-Cell Lymphoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we propose that suppression of p53 by Notch is a key mechanism underlying the initiation of T-cell lymphoma.
|
16103066 |
2005 |
T-Cell Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Polymerase chain reaction-single strand conformation polymorphism followed by direct sequencing revealed TP53 mutations in 45.9% of B cell and 53.8% of T cell lymphomas.
|
16131817 |
2005 |
T-Cell Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although the incidence of thep53, N- and K-ras, and beta-catenin gene mutations is not high, p53 missense mutation has a prognostic value for aggressive course in nasal NK/T-cell lymphoma.
|
14745729 |
2004 |
T-Cell Lymphoma
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Analysis of p53, K-ras, c-kit, and beta-catenin gene mutations in sinonasal NK/T cell lymphoma in northeast district of China.
|
12824925 |
2003 |
T-Cell Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Of these cases, three showed transformation to diffuse large B-cell lymphoma. p53 alteration was also associated with relapse of de novo diffuse large B-cell lymphoma and T-cell non-Hodgkin's lymphoma, as 2/5 (40%) diffuse large B-cell lymphomas and 3/9 (33%) T-cell non-Hodgkin's lymphomas with normal p53 at diagnosis showed p53 alterations at relapse.
|
12383214 |
2002 |
T-Cell Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Mutations of p53 (exons 4 through 8), K-ras (exons 1 and 2), c-kit (exons 11 and 17), and beta-catenin genes (exon 3) in 12 cases of these diseases were analyzed by PCR single strand conformation polymorphism and then by direct sequencing. p53 gene mutations were detected in 5 of 5 cases of peripheral T-cell lymphoma, 3 (60%) of 5 cases of adult T-cell leukemia/lymphoma, and 1 of 2 cases of NK/T cell lymphoma.
|
11896204 |
2002 |
T-Cell Lymphoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Finally, all lymphoblastic T-cell lymphomas (5 cases) and gammadelta hepatosplenic T-cell lymphomas (3 cases) were negative for expression of p53 and p21 proteins.
|
11230707 |
2001 |
T-Cell Lymphoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to analyze the status of the p53 gene, and correlate it with the expression of p53 protein and its downstream target, the cyclin-dependent kinase inhibitor p21, in a series of 25 cases of well-characterized nasal NK/T-cell lymphoma from Mexico.
|
11733360 |
2001 |
T-Cell Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Expression and mutations of the p53 gene were examined in the paraffin-embedded specimens of the nasal lesions from 42 Chinese (Beijing and Chengdu) and Japanese (Okinawa and Osaka) patients with nasal NK/T-cell lymphoma by the immunohistochemistry and single strand conformation polymorphism (SSCP) analysis of polymerase chain reaction (PCR) amplified products followed by direct sequencing.
|
10780666 |
2000 |
T-Cell Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The p63 and p73 genes are rarely mutated in human cancer, although p73 loss is observed in neuroblastoma and a subtype of T-cell lymphoma. p53, p63 and p73 appear to have overlapping and distinct functions: p53 regulates the stress response to suppress tumors; p63 is essential for ectoderm development; and p73 might regulate both the stress response and development.
|
10769197 |
2000 |
T-Cell Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Disrupted p53 function as predictor of treatment failure and poor prognosis in B- and T-cell non-Hodgkin's lymphoma.
|
10353742 |
1999 |
T-Cell Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Sixty-six samples from 55 patients with primary cutaneous B cell and T cell lymphomas were analyzed for mutations in exons 5-9 of the P53 gene using polymerase chain reaction/single strand conformational polymorphism, and subsequent cloning and sequencing of genomic DNA.
|
10084308 |
1999 |
T-Cell Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Twenty primary central nervous system lymphomas (PCNSL) from immunocompetent patients (nineteen B-cell lymphomas and one T-cell lymphoma) were investigated for genetic alterations and/or expression of the genes BCL2, CCND1, CDK4, CDKN1A, CDKN2A, MDM2, MYC, RB1, REL, and TP53.
|
9546285 |
1998 |