|
Adult Soft Tissue Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among these mechanisms, the tumor suppressor p53 (TP53) plays significant roles in the suppression of bone and soft tissue sarcoma progression.
|
31276706 |
2019 |
|
Adult Soft Tissue Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We performed whole-exome sequencing (WES) in a familial aggregation of three individuals affected with soft-tissue sarcoma (STS) without TP53 mutation (Li-Fraumeni-like, LFL) and found a shared pathogenic mutation in <i>CDKN2A</i> tumour suppressor gene.
|
28592523 |
2017 |
|
Adult Soft Tissue Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate whether TP53 DNA mutational status impacts progression-free survival (PFS) in patients with advanced sarcomas (soft tissue sarcoma) treated with vascular endothelial growth factor receptors (VEGFR) inhibition.
|
26646755 |
2016 |
|
Adult Soft Tissue Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to explore the efficacy and define mechanisms of action of PRIMA-1(MET) as a TP53 targeted therapy in soft-tissue sarcoma (STS) cells.
|
26463477 |
2015 |
|
Adult Soft Tissue Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mutational analysis of p53 and PTEN in soft tissue sarcoma.
|
22052239 |
2012 |
|
Adult Soft Tissue Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Clinically relevant TP53 germline mutations were identified in three of the four patients (75%) with a family history of at least two LFS-linked cancers (breast, bone or soft tissue sarcoma, brain tumors or adrenocortical cancer); 1 of the 17 patients (6%) with a family history of breast cancer only, and 1 of the 62 patients (< 2%) with no family history of breast or LFS-linked cancers.
|
22507745 |
2012 |
|
Adult Soft Tissue Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Reactivation of p53 tumor suppressor activity in diseases such as soft-tissue sarcoma is considered an attractive means of targeted therapy.
|
21159888 |
2011 |
|
Adult Soft Tissue Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Germline TP53 mutations are found in Li-Fraumeni syndrome (LFS) patients, predisposed to soft tissue sarcoma and other malignancies.
|
21484931 |
2011 |
|
Adult Soft Tissue Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Using cross species genomic analysis, we define a geneset from the LSL-Kras(G12D); Trp53(Flox/Flox) mouse model of soft tissue sarcoma that is highly enriched in human MFH.
|
19956606 |
2009 |
|
Adult Soft Tissue Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations of the p53 gene have been found in different types of soft tissue sarcoma.
|
18855997 |
2008 |
|
Adult Soft Tissue Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
High prevalence of p53 exon 4 mutations in soft tissue sarcoma.
|
17429838 |
2007 |
|
Adult Soft Tissue Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Wild-type p53 inhibits nuclear factor-kappaB-induced matrix metalloproteinase-9 promoter activation: implications for soft tissue sarcoma growth and metastasis.
|
17077165 |
2006 |
|
Adult Soft Tissue Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We examined the susceptibility of five human bone and soft tissue sarcoma cell lines to transfection with recombinant p53 adenovirus vector (AxCA-p53).
|
11295094 |
2001 |
|
Adult Soft Tissue Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cancer Res., 4: 1985-1994, 1998; M. Milas et al., Cancer Gene Ther., in press, 2000) have shown that the restoration of wild-type (wt) p53 enhances cell cycle control in vitro and inhibits the growth of human soft-tissue sarcoma in severe combined immunodeficient mice.
|
10910082 |
2000 |
|
Adult Soft Tissue Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Soft tissue sarcoma (STS) also develops, though less frequently, in burn scars. p53 gene mutations were analyzed in paraffin-embedded specimens from 5 patients with STS (4 males and 1 female) that had arisen in a burn scar, by means of polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) followed by direct sequencing.
|
10359041 |
1999 |
|
Adult Soft Tissue Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A tumorigenic connection between the oncogene product Mdm2 and tumor suppressor p53 is generally accepted, but their possible clinical relevance has not yet been investigated sufficiently in soft tissue sarcoma.
|
9528860 |
1998 |
|
Adult Soft Tissue Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The ability to restore wt p53 growth-regulatory functions in soft-tissue sarcoma may ultimately be useful as a future therapy in patients with soft-tissue sarcomas.
|
9717829 |
1998 |
|
Adult Soft Tissue Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Molecular assessment of clonality leads to the identification of a new germ line TP53 mutation associated with malignant cystosarcoma phyllodes and soft tissue sarcoma.
|
10207667 |
1998 |
|
Adult Soft Tissue Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutation of the p53 tumor suppressor gene, with resultant overexpression of p53 protein, frequently occurs in human soft tissue sarcomas, supporting the role of p53 mutations in the pathogenesis of soft tissue sarcoma and the possible usefulness of p53 immunolocalization as a screening method for p53 mutations.
|
9140310 |
1997 |
|
Adult Soft Tissue Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Prognosis is correlated with p53 mutation type for soft tissue sarcoma patients.
|
8797580 |
1996 |
|
Adult Soft Tissue Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Sixty-two soft tissue sarcoma samples were investigated for the presence of p53 mutations and for p53 immunoreactivity.
|
8630896 |
1995 |
|
Adult Soft Tissue Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In a preliminary study, we observed that TP53 mutations and nuclear overexpression of p53 protein were frequent events in soft-tissue sarcoma, and we noticed an association between p53-positive phenotype and poor clinical outcome.
|
8133539 |
1994 |
|
Adult Soft Tissue Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The most common cancers occurring in the 41 families with germline p53 mutations, in common with classic LFS, were bone and soft tissue sarcoma, breast cancer, brain tumors, leukemia, and adrenocortical carcinoma, although less than one-half of the probands with germline p53 mutations came from classic LFS families.
|
8118819 |
1994 |
|
Adult Soft Tissue Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Abnormalities of the p53 gene were found in several classes of soft tissue sarcoma, including leiomyosarcomas, rhabdomyosarcomas and malignant fibrous histiocytomas.
|
2216456 |
1990 |