TP53, tumor protein p53, 7157

N. diseases: 2494; N. variants: 527
Disease: Adult type dermatomyositis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0221056
Disease: Adult type dermatomyositis
Adult type dermatomyositis 		0.020 AlteredExpression disease BEFREE This upregulation was closely associated with p53 expression and type I interferon-regulated inflammation, suggesting that upregulation of autoantigens in the skin and muscle of patients with DM might be driven by cellular stress. 28639716 2017
CUI: C0221056
Disease: Adult type dermatomyositis
Adult type dermatomyositis 		0.020 AlteredExpression disease BEFREE We suggest that dermatomyositis-like eruption and hydroxyurea-associated squamous dysplasia represent similar clinical manifestations of a common underlying chronic phototoxic process involving aberrant keratinocyte p53 expression mediated by hydroxyurea's antimetabolite properties and UV radiation exposure. 20231502 2010