Malignant neoplasm of liver
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, based on phylogenetic analysis, the characteristic mutations were found in the initiating malignant clones in the AA-implicated mouse and human liver cancers where the mutations of tumor protein p53 and Janus kinase 1 were prone to be significantly enriched in the AA-affected human tumors.
|
31692012 |
2020 |
Malignant neoplasm of liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our results suggested that ALX4 was inactivated by DNA methylation and played a tumor suppressor function through the P53 pathway in MC-LR induced liver cancer.
|
31132711 |
2019 |
Malignant neoplasm of liver
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Correlation between expression levels of PTEN and p53 genes and the clinical features of HBsAg-positive liver cancer.
|
28952211 |
2019 |
Malignant neoplasm of liver
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Majority of AFB1 associated hepatocellular cancer cases carry TP53 mutant DNA, which is an indicator of AFB1 exposure, as well as hepatocellular cancer risk.
|
30594067 |
2019 |
Malignant neoplasm of liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
Among of them, p53 and p21 genes played a vital role in the development of liver cancer.
|
31357283 |
2019 |
Malignant neoplasm of liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study tests a hypothesis that HDAC11 prevents LC cell (LCC) apoptosis via modulating the p53 gene transcription.
|
30899397 |
2019 |
Malignant neoplasm of liver
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We developed liver cancer cell lines that endogenously expressed a mutant form of TP53 (R249S) or overexpressed mutant forms of STAT3 (D170Y, K348E, and Y640F) or JAK1 (S703I and L910P) and tested the abilities of pharmacologic agents to reduce activity.
|
31560893 |
2019 |
Malignant neoplasm of liver
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
LncRNA SNHG1 promotes liver cancer development through inhibiting p53 expression via binding to DNMT1.
|
31002127 |
2019 |
Malignant neoplasm of liver
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
A mouse model of liver cancer reveals that downregulation of mevalonate pathway gene expression by p53 occurs in premalignant hepatocytes, when p53 is needed to actively suppress tumorigenesis.
|
30580964 |
2019 |
Malignant neoplasm of liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
In a second approach, functional wild type p53 is delivered into p53-null liver cancer (Hep3B) cells, sensitizing the cells toward the p53 pathway drug, Nutlin.
|
29802765 |
2019 |
Malignant neoplasm of liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
In summary, lncRNA‑PURPL was proposed to promote cell proliferation in liver cancer by regulating the p53 gene.
|
31059022 |
2019 |
Malignant neoplasm of liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
Nucleoporin Nup155 is part of the p53 network in liver cancer.
|
31089132 |
2019 |
Malignant neoplasm of liver
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
RAMP3 is a prognostic indicator of liver cancer and might reduce the adverse effect of TP53 mutation on survival.
|
29882679 |
2018 |
Malignant neoplasm of liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
We observed RBM38 protein expression was commonly silenced coupled with increased mdm2 and decreased wild type (wt) p53 in liver cancer cells and HCC tissues compared to the corresponding normal liver cells and adjacent liver tissues.
|
30176896 |
2018 |
Malignant neoplasm of liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
For the first time, it was shown the possibility to induce the exogenous expression of the pro-apoptotic gene TRAIL and p53 in a liver cancer HepG2 cells via a sonoporation procedure.
|
30181808 |
2018 |
Malignant neoplasm of liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here we found that suppressing TIP60 inhibited p53 K120 acetylation and thus rescued apoptosis induced by glucose deprivation in hepatocellular cancer cells.
|
29174981 |
2018 |
Malignant neoplasm of liver
|
0.600 |
Biomarker
|
disease |
RGD |
Effect of human umbilical cord blood derived CD34+ hematopoietic stem cell on the expression of Wnt4 and P53 genes in a rat model of hepatocellular carcinoma.
|
29429512 |
2018 |
Malignant neoplasm of liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
Meanwhile, Dios-induced liver cancer cell apoptosis was related with the p53 activation.
|
28240165 |
2017 |
Malignant neoplasm of liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
We conclude that repression of GMPS by p53 through p21 is a functionally relevant part of the p53-mediated senescence program limiting tumor cell growth in liver cancer.
|
27939741 |
2017 |
Malignant neoplasm of liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results suggested that ROS and p53 reciprocally promoted each other's production and cooperated to induce liver cancer cell death.
|
28673807 |
2017 |
Malignant neoplasm of liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
The hepatocellular abundance of phosphorylated PKR is elevated in HCV-infected chimpanzees, suggesting that PKR activation and consequent p53 inhibition accompany HCV infection <i>in vivo</i> These findings reveal a feature of the host response to HCV infection that may contribute to hepatocellular carcinogenesis.<b>IMPORTANCE</b> Chronic infection with hepatitis C virus (HCV) is the leading cause of liver cancer in most developed nations.
|
28442604 |
2017 |
Malignant neoplasm of liver
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Ultimately, P53 (N340Q/L344R) accerlerates the growth of liver cancer cells Hep3B by activating telomerase and prolonging telomere through the cascade of P53 (N340Q/L344R)-CUDR-PKM2-pH3T11- (H3K9me1-HP1α)-Pim1- (TERT-HOTAIR-TERRA).
|
27167190 |
2016 |
Malignant neoplasm of liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
Since hepatitis B and C viral proteins lead to inactivation of the tumor suppressors p53 and Retinoblastoma (Rb), we hypothesize that surgery in the context of p53/Rb inactivation initiate de novo tumorigenesis.We, therefore, generated transgenic mice with hepatocyte and cholangiocyte/liver progenitor cell (LPC)-specific deletion of p53 and Rb, by interbreeding conditional p53/Rb knockout mice with either Albumin-cre or Cytokeratin-19-cre transgenic mice.We show that liver cancer develops at the necrotic injury site after surgical resection or radiofrequency ablation in p53/Rb deficient livers.
|
27323406 |
2016 |
Malignant neoplasm of liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
NUMB phosphorylation destabilizes p53 and promotes self-renewal of tumor-initiating cells by a NANOG-dependent mechanism in liver cancer.
|
26174965 |
2015 |
Malignant neoplasm of liver
|
0.600 |
Biomarker
|
disease |
BEFREE |
One such example is hepatitis virus-induced liver cancer whereby p53 is inactivated upon the binding of a specific viral protein, leading to the loss of its tumor suppressive activity.
|
25404244 |
2014 |