TP53, tumor protein p53, 7157
N. diseases: 2494; N. variants: 527
Source: ALL
| Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year |
|---|---|---|---|---|---|---|---|
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0.100 | Biomarker | disease | BEFREE | This review discusses the multiple roles of the CagA protein encoded by the cag pathogenicity island of Helicobacter pylori and highlights the CagA degradation activities on p53. | 24097901 | 2013 |
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0.100 | GeneticVariation | disease | BEFREE | Helicobacter pylori cause damage to gastric epithelial cells and alterations in the p53 gene that lead to cancer development. | 24042100 | 2013 |
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0.100 | GeneticVariation | disease | BEFREE | The purpose of this study was to evaluate the association of p53 codon 72 genetic polymorphism and the p53 immunohistochemistry with Helicobacter pylori-associated gastroduodenal diseases, including gastric cancer. | 19184427 | 2010 |
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0.100 | GeneticVariation | disease | BEFREE | Gastric adenocarcinoma and Helicobacter pylori: correlation with p53 mutation and p27 immunoexpression. | 20541486 | 2010 |
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0.100 | AlteredExpression | disease | BEFREE | Helicobacter pylori-induced gastric epithelial cell (GEC) apoptosis is a complex process that includes activation of the tumor suppressor p53. p53-mediated apoptosis involves p53 activation, bax transcription, and cytochrome c release from mitochondria. | 19505426 | 2009 |
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0.100 | Biomarker | disease | BEFREE | Interaction of Helicobacter pylori with gastric epithelial cells is mediated by the p53 protein family. | 18343378 | 2008 |
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0.100 | Biomarker | disease | BEFREE | In 494 control subjects and 284 gastric carcinoma patients, serum APCA was evaluated and all subjects and patients were classified into four groups using serologic markers (anti-Hp IgG antibody and pepsinogen (PG) test: positive; PG I < 70 microg/L and PG I/II ratio < 3.0) as follows: A, HP- PG-; B, HP+ PG-; C, HP+ PG+ and D, HP- PG+. p53 mutations were analyzed in 174 of 284 patients. | 16638096 | 2006 |
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0.100 | Biomarker | disease | BEFREE | To investigate the relationship between Helicobacter pylori (H pylori) infection, microsatellite instability and the expressions of the p53 in gastritis, intestinal metaplasia and gastric adenocarcinoma and to elucidate the mechanism of gastric carcinogenesis relating to H pylori infection. | 16038035 | 2005 |
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0.100 | AlteredExpression | disease | BEFREE | Mutant p53 expression and apoptotic activity of Helicobacter pylori positive and negative gastritis in correlation with the presence of intestinal metaplasia. | 12655259 | 2003 |
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0.100 | AlteredExpression | disease | BEFREE | Reactive oxygen species (ROS) may participate in the production of mutations and the inactivation of p53 is due to infection by the bacterium Helicobacter pylori. | 14520466 | 2003 |
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0.100 | GeneticVariation | disease | BEFREE | However, there have been no reports on the p53 codon 72 polymorphism in gastric cancer susceptibility in patients with Helicobacter pylori-associated chronic gastritis (H. pylori-CG). | 12115545 | 2002 |
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0.100 | AlteredExpression | disease | BEFREE | Gastric cancer is often associated with p53 over-expression and Helicobacter pylori (HP) infection. | 11396149 | 2001 |
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0.100 | Biomarker | disease | BEFREE | Helicobacter pylori eradication therapy for high-grade mucosa-associated lymphoid tissue lymphomas of the stomach with analysis of p53 and K-ras alteration and microsatellite instability. | 11351252 | 2001 |
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0.100 | AlteredExpression | disease | BEFREE | Morphometric and immunohistochemical techniques were used to analyse DNA content, p53 and c-myc oncogene expression and cell proliferation on gastric biopsies of 53 children (27 Helicobacter pylori-negative and 26 Helicobacter pylori-positive). | 11838608 | 2001 |
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0.100 | Biomarker | disease | BEFREE | The authors studied the histopathologic and histochemical features of several gastric specimens of nine members of this family and searched for the expression of carcinoembryonic antigen (CEA), p21 protein (ras oncogene), p53 protein (p53 suppressor gene), and simple mucin-type carbohydrate antigens (Tn, sialosyl-Tn, and T antigen before and after neuraminidase) and for the presence of Helicobacter pylori. | 8319165 | 1993 |