Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The p53 tumor suppressor protein is a transcription factor that plays a prominent role in protecting cells from malignant transformation.
|
31665549 |
2020 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The first event is mutation or methylation of the TP53 promoter, leading to appearance of a cell with increased risk of malignant transformation.
|
30871527 |
2019 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Despite heightened research interest over the last four decades, a clear picture of how wild type HsP53 functions as the guardian against malignant transformation remains elusive.
|
31520351 |
2019 |
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
These results suggest that loss of p53 function and activation of phosphatidylinositol 3-kinase-AKT signaling pathways played important pathogenic roles in malignant transformation of the present case.
|
30379345 |
2019 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
MDM2 can mediate the degradation of tumor suppressor p53 through an autoregulatory feedback loop, in which MDM2 abolishes wild-type p53 function and accelerates malignant transformation.
|
31134974 |
2019 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Higher intensity of p53 stained keratinocytes, no matter their low number, could represent mutant and more stable form of p53 protein, and at the same time signal for monitoring of disease due to potential malignant transformation.
|
29135114 |
2019 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Malignant neoplasia was found more frequently in patients with p53+ (P = .0006, OR = 7.67 [2.30; 25.54]) and PTEN- (P = .0043; OR = 5.43 [1.77; 16.61]).Immunohistochemical analysis using p53 and PTEN as markers, either alone or concomitantly, can be useful to predict malignant transformation in cases of endometrial polyps.
|
30235677 |
2018 |
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Because aberrant phosphorylation of cellular proteins is a hallmark of malignant transformation, the expression of the phosphorylated epitope could be an ideal antigen to combat cancer without damaging normal tissues. p53 activates transcription factors to suppress tumors by upregulating growth arrest and apoptosis-related genes.
|
30510853 |
2018 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The p53 tumor suppressor plays a critical role in protecting normal cells from malignant transformation.
|
29483299 |
2018 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The MDM2 homolog MDMX oncoprotein is indispensable for inhibition of p53 during normal embryonic development and malignant transformation, yet how MDMX harnesses p53 functions is unclear.
|
29581299 |
2018 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Thus, increased expression of cyclin D1 and cyclin E may be involved in cell cycle progression in psoriatic epidermis, and pRb and p53 may play important roles in the prevention of malignant transformation under the hyperproliferative state in psoriasis.
|
29115643 |
2018 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In agreement with the permissive role of TP53 mutations to oncogenic events, this report strongly suggests that TP53 mutations may promote malignant transformation of proliferating trophoblastic cells.
|
28477316 |
2018 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Thus, the author concludes that p53 and EGFR are useful biomarkers for the diagnosis of leukoplakia and their risk of malignant transformation.
|
29516925 |
2018 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
This study assessed mutations in KRAS and p53 gene in blood as a screening tool for malignant transformation in CP patients.
|
29303908 |
2018 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Mutations of TP53 or inactivation of its gene product are among the first events initiating malignant transformation.
|
29569948 |
2018 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Indeed, a large body of work has shown that dysregulation of p53 and its E3 ligase MDM2 by the ubiquitin-proteasome system (UPS) promotes carcinogenesis and malignant transformation.
|
28587923 |
2017 |
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The results of our study suggest that amarogentin promotes apoptosis of liver cancer cells by the upregulation of p53 and downregulation of human telomerase reverse transcriptase and prevents the malignant transformation of these cells.
|
27402632 |
2017 |
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The tumor suppressor p53 is activated in response to cellular stress to prevent malignant transformation.
|
29046333 |
2017 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In individuals with a competent immune-system, p53 LOH independent pathways may induce malignant transformation which requires a longer tumor latency.
|
28008605 |
2017 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The p53 tumor suppressor serves as a major barrier against malignant transformation.
|
26943582 |
2016 |
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In response to various cellular stresses, p53 is activated and inhibits malignant transformation through the transcriptional regulation of its target genes.
|
26757339 |
2016 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We also examined TP53 and MDM2 protein immunohistochemistry (IHC) to assess the involvement of these differences in malignant transformation and disease progression.
|
25734904 |
2015 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Our study suggests that: (1) polysomy 6 and p16 deletion may contribute to adenomatous change of IPMN; (2) polysomy 7, polysomy 18, p16 deletion, and p53 deletion play roles in malignant transformation of noninvasive IPMN; and (3) polysomy 7 and p53 deletion may be excellent diagnostic markers for invasive IPMN.
|
25517961 |
2015 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Understanding the function of p53 in stem cells and its role in maintaining the balance between differentiation and malignant transformation can help shed light on cancer initiation and propagation, and hopefully also on cancer prevention and therapy.
|
24406212 |
2015 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We demonstrated that Skp2 inactivation decreased H3K4me3 levels, along with a reduction of cell growth, cell migration and malignant transformation of Pten/Trp53 double null MEFs, and further restrained prostate tumorigenesis of Pten/Trp53 mutant mice.
|
25596733 |
2015 |