|
TARSAL-CARPAL COALITION SYNDROME
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Deletion of exon 1 of TP53 gene has occurred in 11 (35.4%) patients with TCC.
|
26685928 |
2016 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A direct statistically significant association was detected between c-erb-B2 expression and Bcl-2 and p53 expression in TCC and SCC specimens.
|
26653553 |
2015 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
While the deregulation of both the cell cycle and the apoptotic pathways was particularly related to TCC, these alterations were not associated with the TP53 status.
|
21116856 |
2011 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Brenner tumors and TCCs differed mainly in the expression of EGFR, p16, and p53.
|
19033864 |
2009 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To determine the prognostic value of p53 gene mutations and P53 overexpression for predicting the incidence of recurrence, progression and long-term survival of patients with transitional cell carcinoma (TCC) of the bladder.
|
18367096 |
2009 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest that VEGF, KDR and p53 might be valuable biomarkers in prognosis of TCC patients.
|
18645275 |
2008 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.100 |
Biomarker
|
disease |
BEFREE |
To analyze the correlation between the genotypic and phenotypic patterns of p53 in patients with transitional cell carcinoma (TCC) of the urinary bladder.
|
18025850 |
2007 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We investigated expression patterns of CD44s and CD44v6 in transitional cell carcinoma (TCC) of the urinary bladder in relation to tumour grade, proliferative activity, and immunoreactivity for p53.
|
18092951 |
2007 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.100 |
Biomarker
|
disease |
BEFREE |
This prompted our investigation to explore the global Alu methylation and the promoter methylation of the novel putative tumor suppressor genes caveolin-1 and hDAB2IP, and of p53 in transitional cell carcinomas (TCC), squamous cell carcinomas and undifferentiated small cell carcinomas of the urinary bladder.
|
16328005 |
2006 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results were compared to the mutation frequency of TP53 in urine sediments from patients diagnosed with transitional cell carcinoma (TCC) of the bladder and healthy controls.
|
16903935 |
2006 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Clonality was tested in 86 tumours from 25 patients with recurrent and multifocal superficial bladder transitional cell carcinomas (TCCs) using the analysis of TP53 mutations and of LOH in the 17p13 and 9p21 regions.
|
16343743 |
2006 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Four of the five TCC lines expressed mutant p53.
|
14679155 |
2003 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied whether p53 status has any predictive value on the outcome of intravesical adriamycin (ADR) instillation for superficial transitional cell carcinoma (TCC) of the bladder.
|
12926093 |
2003 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gemcitabine alone had a dose-dependent cytotoxic and apoptosis inducing effect on all TCC cell lines independent of p53 status.
|
12597983 |
2003 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.100 |
Biomarker
|
disease |
BEFREE |
This approach could be useful in targeting apoptosis to TCC and other carcinomas lacking p53 and RB function.
|
12370752 |
2002 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The prevalence of cases with p53 mutations within Arg72-containing allele was higher for advanced-stage TCCs (chi(2) = 5.320, P = 0.021) than for TCCs with those arising in Pro72-containing allele.
|
12006537 |
2002 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.100 |
Biomarker
|
disease |
BEFREE |
The high-grade dysplasia/CIS group (n = 16) had a similar high percentage and intensity of p53 staining (45.3 +/- 4.3%; 28.2 +/- 6.1 arbitrary units [AU]) as the TCC group (n = 16.
|
12607601 |
2002 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The expression pattern of PAX5 in the tissue of superficial bladder transitional cell carcinoma (TCC), its prognostic value and its correlation with p53 immunohistochemistry and p53 mutation analysis were evaluated.
|
14577491 |
2002 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine prognostic factors for survival in bladder transitional cell carcinoma (TCC), and the prognostic value of p53 and ki67.
|
12074407 |
2002 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.100 |
Biomarker
|
disease |
BEFREE |
These in vivo findings indicate that Ser392 phosphorylation frequently occurs in mutant form p53 in TCCs.
|
12081208 |
2002 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the roles of p53 and bcl-2 as prognostic factors in TCC of bladder in patients younger than 40 years.
|
11464113 |
2001 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.100 |
Biomarker
|
disease |
BEFREE |
The underlying molecular changes of carcinoma in situ involve multiple and more extensive deletions (normally TP53-defective) than coexistent invasive TCC, suggesting an independent genetic evolution, while low-grade dysplasia is mainly polyclonal and shows a low rate of gene deletions.
|
11315626 |
2001 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the feasibility and activity of paclitaxel, carboplatin, and methotrexate in advanced transitional cell carcinoma (TCC) of the urothelium and to relate the activity of this combination to the mutational status of p53.
|
10736495 |
2000 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of the present study was to evaluate the prognostic relevance of p53 expression in T1 TCC of the bladder.
|
10828662 |
2000 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
As expected, none of eight TCCs with mutant p53 responded to gamma radiation by elevation of p53, p21(WAF1), or mdm2 or by cell cycle arrest.
|
10919661 |
2000 |