TPH1, tryptophan hydroxylase 1, 7166

N. diseases: 127; N. variants: 11
Disease: Borderline Personality Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006012
Disease: Borderline Personality Disorder
Borderline Personality Disorder 		0.070 GeneticVariation disease BEFREE Variation in TPH1 may increase risk for developing BPD as a result of childhood abuse. 21989108 2012
CUI: C0006012
Disease: Borderline Personality Disorder
Borderline Personality Disorder 		0.070 GeneticVariation disease BEFREE Results suggest that the A allele of the tryptophan hydroxylase-1 A218 polymorphism may be associated with BPD, and that it does not appear to be related to suicidal behavior in this population. 18506706 2009
CUI: C0006012
Disease: Borderline Personality Disorder
Borderline Personality Disorder 		0.070 GeneticVariation disease BEFREE Furthermore, the TPH-1 haplotype displayed a significantly higher frequency in BPD participants with impaired decision making, compared to BPD participants with normal scores. 18826425 2009
CUI: C0006012
Disease: Borderline Personality Disorder
Borderline Personality Disorder 		0.070 GeneticVariation disease BEFREE The 5-HT1A, 5-HT1B, 5-HT1D, 5-HT3A and TPH1 showed no significant association with BPD for genotype, allele and haplotype analyses. 19032968 2009
CUI: C0006012
Disease: Borderline Personality Disorder
Borderline Personality Disorder 		0.070 GeneticVariation disease BEFREE These data suggested an interaction between the 2 TPH genes to confer a risk for BPD. 17768266 2007
CUI: C0006012
Disease: Borderline Personality Disorder
Borderline Personality Disorder 		0.070 GeneticVariation disease BEFREE We aimed to determine whether specific TPH-1 haplotypes associate with BPD.A case-control design was employed. 16495936 2006
CUI: C0006012
Disease: Borderline Personality Disorder
Borderline Personality Disorder 		0.070 Biomarker disease BEFREE This study was designed to investigate sequence variants of the TPH1 gene in Taiwanese and to test whether the TPH1 gene is a susceptibility factor for the BPD. 15799788 2005