Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This study took the approach to screen for an anti-depressive Bifidobacterium longum strain from fourteen candidates and systematically verified its effect in a chronic stress-induced depression mice model.B. longum subsp. infantis strain CCFM687 could significantly enhance the biosynthesis of 5-hydroxytryptamine (5-HTP) in vitro in RIN14B cells through up-regulation of the Tph1 gene expression.
|
31687714 |
2019 |
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
BDNF mediates the protective effects of scopolamine in reserpine-induced depression-like behaviors via up-regulation of 5-HTT and TPH1.
|
30529315 |
2019 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated gray matter volume (GMV) differences, TPH1 rs1800532 and rs1799913 polymorphisms previously found to be associated with depressive disorder and SB, and the relationship between the two markers.
|
30602107 |
2018 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, the T/T homozygote of c.-1668T>A-TPH1, the G/T heterozygote and T allele of c.-844G>T-TPH2, and the C/C homozygote and C allele of c.-1449C>A-TPH2 decreased the risk of development of depressive disorders.
|
29314569 |
2018 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The results indicate that there exists possible interrelation between TH and TPH gene expression and epigenetic histone acetylation in CUS-induced depressive rats, which at least partly contributes to the etiology of depression.
|
24495952 |
2014 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Common polymorphisms involved in the tryptophan hydroxylase 1 (TPH1) and 2 (TPH2), serotonin transporter, monoamine oxidase A (MAOA) and brain-derived neurotrophic factor (BDNF) were investigated in a naturalistic inpatient study of the German research network on depression.
|
23063133 |
2013 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Clinical and molecular genetics of psychotic depression.
|
23512949 |
2013 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Common polymorphisms involved in the tryptophan hydroxylase 1 (TPH1) and 2 (TPH2), serotonin transporter, monoamine oxidase A (MAOA) and brain-derived neurotrophic factor (BDNF) were investigated in a naturalistic inpatient study of the German research network on depression.
|
23063133 |
2013 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Two functional polymorphisms of the serotonin transporter gene, 5-HTTLPR and STin2 have been investigated in a large number of pharmacogenetic studies of depression; other candidate genes include serotonin receptor genes, brain-derived neurotrophic factor, P-glycoprotein (located in the blood-brain barrier), G-proteins, TPH1 and TPH2, MAOA, the noradrenaline transporter gene, FKBP5, or cytochrome P450 (CYP450) genes.
|
19738481 |
2009 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Tryptophan hydroxylase-1 (TPH1) is the rate-limiting enzyme in serotonin biosynthesis, and allelic variations at the TPH1 locus have been implicated in the pathophysiology of depression.
|
19500158 |
2009 |
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Tryptophan hydroxylase gene (TPH1) and peripheral tryptophan levels in depression.
|
18177948 |
2008 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The tryptophan hydroxylase (TPH) 2 gene unlike TPH-1 exhibits no association with stress-induced depression.
|
17692928 |
2008 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
While genetic association and mRNA expression studies implicate the tryptophan hydroxylase isoform-1 gene (TPH1) in depression and suicidality, the TPH1 gene is 150-fold less expressed in mouse brain than TPH2.
|
15941494 |
2006 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
To our knowledge, this is the first study to report an association of the 3' end of TPH1 with continuous measures of depression and anxiety.
|
15729745 |
2005 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Specifically, we investigated two serotonin-related genes including three substitutions connected to human emotional states such as despondency and depression: the tryptophan hydroxylase (TPH) gene (A779C and A218C in the intron) and the serotonin1A (5-HT1A) receptor gene (Pro 16Leu in the cording region).
|
14998306 |
2004 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Five single nucleoside polymorphisms of the TPH1 gene were studied in a population-based sample of postpartum Taiwanese women consisting of 120 subjects with depression or/and anxiety and 86 matched normal controls.
|
15544576 |
2004 |