TPH1, tryptophan hydroxylase 1, 7166

N. diseases: 127; N. variants: 11
Disease: Diarrhea ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011991
Disease: Diarrhea
Diarrhea 		0.030 GeneticVariation phenotype BEFREE Only the group of patients with diarrhea-predominant irritable bowel syndrome showed a significant correlation between the TPH1 rs211105 T/T genotype and lower scores for role physical and mental health, and higher scores for indigestion and diarrhea. 29892168 2018
CUI: C0011991
Disease: Diarrhea
Diarrhea 		0.030 GeneticVariation phenotype BEFREE The mean scores of diarrhea at baseline were significantly higher (5.2 vs 3.7, p = 0.005) in patients with TPH1 rs211105 T/T than those with the G allele. 25428414 2015
CUI: C0011991
Disease: Diarrhea
Diarrhea 		0.030 Biomarker phenotype BEFREE However, among IBS patients, all five TPH1 SNPs showed some association with diarrhea and loose type of stool consistency, with P-values rating from 0.01 to 0.20. 21073637 2011