|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interestingly, (i) the expression of three of these six genes (COMT, DBH, NOS1) are highly variable; (ii) three of these six genes (COMT, DBH, TPH1) are involved in DA or serotonin metabolism, biosynthesis and/or neurotransmission; and (iii) five of these six genes (AR, BDNF, COMT, DBH, NOS1) have been implicated in the development, onset and/or propagation of schizophrenia.
|
28443016 |
2017 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
While the TPH1 gene has been found to be associated with schizophrenia, studies focusing on TPH2 variants did not yield conclusive results for schizophrenia or the response to antipsychotic medication.
|
22655589 |
2012 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The TPH1 CC genotype had 2.7-fold higher odds of crime-related schizophrenia compared with A-carrier genotype after the analysis was controlled for sex and age (OR, 2.69; 95% CI, 1.22 - 5.91; P = .01).
|
22053918 |
2012 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No evidence of an association between A218C polymorphism of the tryptophan hydroxylase 1 gene and aggression in schizophrenia in a Korean population.
|
20046510 |
2010 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that neither common genetic variations of TPH1 nor TPH2 are likely to contribute to the genetic susceptibility to schizophrenia in Japanese population.
|
20144688 |
2010 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the TPH1 A218/A779 locus increases the susceptibility of schizophrenia in Caucasian and Asian populations.
|
19526457 |
2010 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
LHGDN |
Schizophrenia and beta-thalassemia: a genetic link?
|
18221792 |
2008 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
|
18583979 |
2008 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our updated meta-analysis, which included six population-based case-control studies, suggests the possible involvement of the TPH1 218A allele in susceptibility to schizophrenia.
|
17870198 |
2007 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
TPH-1 association with schizophrenia is debated.
|
16806098 |
2006 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
LHGDN |
TPH-1 association with schizophrenia is debated.
|
16806098 |
2006 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis shows association between the tryptophan hydroxylase (TPH) gene and schizophrenia.
|
16741719 |
2006 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although the tryptophan hydroxylase isoform-1 gene (Tph1) has been reported to have a genetic association with bipolar disorder and schizophrenia, the Tph1 isoform is expressed at much lower levels than Tph2 (150-fold less in the mouse brain).
|
16240163 |
2005 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Childhood-onset schizophrenia and tryptophan hydroxylase gene polymorphism.
|
15211625 |
2004 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
DNA sequencing of the highly conserved cofactor binding domain of the PAH, TH, and TPH genes in African-American subjects with schizophrenia and unrelated, never mentally ill subjects from the NIMH Schizophrenia Genetics Initiative, was undertaken to assess the concordance of mutant genotype with psychiatric phenotype.
|
12210276 |
2002 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest that the TPH gene may play a role in the negative symptoms in male patients with schizophrenia.
|
11324941 |
2000 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study was designed to examine whether A218C polymorphism, which has been identified in intron 7 of the TPH gene, may be associated with schizophrenia or the suicidal behavior of schizophrenics in the Korean population.
|
10899755 |
2000 |