TPM4, tropomyosin 4, 7171

N. diseases: 48; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0334121
Disease: Inflammatory Myofibroblastic Tumor
Inflammatory Myofibroblastic Tumor 		0.330 GeneticVariation disease BEFREE Pulmonary inflammatory myofibroblastic tumor with TPM4-ALK translocation. 29268561 2017
CUI: C0334121
Disease: Inflammatory Myofibroblastic Tumor
Inflammatory Myofibroblastic Tumor 		0.330 Biomarker disease BEFREE ALK is rendered oncogenic as a result of its fusion to NPM1 in anaplastic large cell lymphoma, to TPM3 or TPM4 in inflammatory myofibroblastic tumor, to EML4 in non-small cell lung carcinoma, and to VCL in renal medullary carcinoma. 22614325 2012
CUI: C0334121
Disease: Inflammatory Myofibroblastic Tumor
Inflammatory Myofibroblastic Tumor 		0.330 FusionGene disease ORPHANET TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors. 10934142 2000
CUI: C0334121
Disease: Inflammatory Myofibroblastic Tumor
Inflammatory Myofibroblastic Tumor 		0.330 Biomarker disease BEFREE TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors. 10934142 2000
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.310 Biomarker disease BEFREE There are various protein factors, such as DDX5, PSMC2, CSNK1A1, PLIN1, ILK, and TPM4, differentially expressed in the bone marrow microenvironment of osteoporotic patients, providing new ideas for finding therapeutic targets for osteoporosis. 30739146 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.310 AlteredExpression phenotype BEFREE TPM4 protein low-expression was obviously associated with clinical stage, T classification (invasion depth), N classification (lymph node metastasis), distant metastasis and differentiation. 29455030 2018
CUI: C0005818
Disease: Blood Platelet Disorders
Blood Platelet Disorders 		0.310 Biomarker group BEFREE Together, our findings demonstrate a nonredundant role for TPM4 in platelet biogenesis in humans and mice and reveal that truncating variants in TPM4 cause a previously undescribed dominant Mendelian platelet disorder. 28134622 2017
CUI: C0005818
Disease: Blood Platelet Disorders
Blood Platelet Disorders 		0.310 Biomarker group GENOMICS_ENGLAND Together, our findings demonstrate a nonredundant role for TPM4 in platelet biogenesis in humans and mice and reveal that truncating variants in TPM4 cause a previously undescribed dominant Mendelian platelet disorder. 28134622 2017
CUI: C2751260
Disease: Macrothrombocytopenia
Macrothrombocytopenia 		0.310 GeneticVariation disease BEFREE N-Ethyl-N-nitrosourea-induced (ENU-induced) missense mutations in Tpm4 or targeted inactivation of the Tpm4 locus led to gene dosage-dependent macrothrombocytopenia in mice. 28134622 2017
CUI: C2751260
Disease: Macrothrombocytopenia
Macrothrombocytopenia 		0.310 Biomarker disease GENOMICS_ENGLAND N-Ethyl-N-nitrosourea-induced (ENU-induced) missense mutations in Tpm4 or targeted inactivation of the Tpm4 locus led to gene dosage-dependent macrothrombocytopenia in mice. 28134622 2017
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.310 Biomarker disease CTD_human Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density. 18924182 2008
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.310 Biomarker phenotype CTD_human Proteomic analysis identifies candidate proteins associated with distant recurrences in breast cancer after adjuvant chemotherapy. 17085005 2007
CUI: C4304021
Disease: Autosomal dominant macrothrombocytopenia
Autosomal dominant macrothrombocytopenia 		0.300 GermlineCausalMutation disease ORPHANET Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia. 28134622 2017
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.300 Biomarker disease CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136 2014
CUI: C0003949
Disease: Asbestosis
Asbestosis 		0.300 Biomarker disease CTD_human Peroxiredoxins and tropomyosins as plasma biomarkers for lung cancer and asbestos exposure. 22537621 2012
CUI: C2930617
Disease: Pulmonary Fibrosis - from Asbestos Exposure
Pulmonary Fibrosis - from Asbestos Exposure 		0.300 Biomarker disease CTD_human Peroxiredoxins and tropomyosins as plasma biomarkers for lung cancer and asbestos exposure. 22537621 2012
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome 		0.300 Biomarker disease CTD_human "Proteomic changes related to ""bewildered"" circulating platelets in the acute coronary syndrome." 21751358 2011
CUI: C0001787
Disease: Osteoporosis, Age-Related
Osteoporosis, Age-Related 		0.300 Biomarker disease CTD_human Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density. 18924182 2008
CUI: C0029459
Disease: Osteoporosis, Senile
Osteoporosis, Senile 		0.300 Biomarker disease CTD_human Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density. 18924182 2008
CUI: C0043094
Disease: Weight Gain
Weight Gain 		0.300 Biomarker phenotype CTD_human Different transcriptional control of metabolism and extracellular matrix in visceral and subcutaneous fat of obese and rimonabant treated mice. 19030233 2008
CUI: C0751406
Disease: Post-Traumatic Osteoporosis
Post-Traumatic Osteoporosis 		0.300 Biomarker disease CTD_human Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density. 18924182 2008
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.300 Biomarker group CTD_human Comparative proteomic analysis of esophageal squamous cell carcinoma. 15986332 2005
CUI: C0032927
Disease: Precancerous Conditions
Precancerous Conditions 		0.300 Biomarker group CTD_human Comparative proteomic analysis of esophageal squamous cell carcinoma. 15986332 2005
CUI: C0282313
Disease: Condition, Preneoplastic
Condition, Preneoplastic 		0.300 Biomarker disease CTD_human Comparative proteomic analysis of esophageal squamous cell carcinoma. 15986332 2005
CUI: C0546837
Disease: Malignant neoplasm of esophagus
Malignant neoplasm of esophagus 		0.300 Biomarker disease CTD_human Comparative proteomic analysis of esophageal squamous cell carcinoma. 15986332 2005