|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Prevalence of TPMT, ITPA and NUDT 15 genetic polymorphisms and their relation to 6MP toxicity in north Indian children with acute lymphoblastic leukemia.
|
30474703 |
2019 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia.
|
30201983 |
2018 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We confirmed that patients with acute lymphoblastic leukemia that carry inactive TPMT allele(s) require 6- mercaptopurine dose reduction.
|
30598629 |
2018 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genomewide Approach Validates Thiopurine Methyltransferase Activity Is a Monogenic Pharmacogenomic Trait.
|
27564568 |
2017 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
An antileukemic agent prescribed for pediatric oncology patients during the maintenance phase of therapy for acute lymphoblastic leukemia, 6-mercaptopurine (6-MP), is highly influenced by genetic variations in the thiopurine S-methyltransferase enzyme.
|
28681659 |
2017 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
NUDT15 and TPMT genetic polymorphisms are related to 6-mercaptopurine intolerance in children treated for acute lymphoblastic leukemia at the Children's Cancer Center of Lebanon.
|
27577869 |
2017 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Thiopurine S-methyltransferase polymorphisms in acute lymphoblastic leukemia, inflammatory bowel disease and autoimmune disorders: influence on treatment response.
|
28507448 |
2017 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Analysis of Thiopurine S-Methyltransferase Deficient Alleles in Acute Lymphoblastic Leukemia Patients in Mexican Patients.
|
28476189 |
2016 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Prevalence of TPMT and ITPA gene polymorphisms and effect on mercaptopurine dosage in Chilean children with acute lymphoblastic leukemia.
|
24774509 |
2014 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms of NQO1, CYP1A1 and TPMT and susceptibility to acute lymphoblastic leukemia in a Tunisian population.
|
23065291 |
2013 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Frequency of thiopurine S-methyltransferase mutant alleles in indigenous and admixed Guatemalan patients with acute lymphoblastic leukemia.
|
23377985 |
2013 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Epistatic interactions between thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) variations determine 6-mercaptopurine toxicity in Indian children with acute lymphoblastic leukemia.
|
22009189 |
2012 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Thiopurine S-methyltransferase (TPMT) polymorphisms in children with acute lymphoblastic leukemia, and the need for reduction or cessation of 6-mercaptopurine doses during maintenance therapy: the Polish multicenter analysis.
|
21319286 |
2011 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Thiopurine methyltransferase polymorphisms and mercaptopurine tolerance in Turkish children with acute lymphoblastic leukemia.
|
21400026 |
2011 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
A cost effectiveness analysis of thiopurine methyltransferase testing for guiding 6-mercaptopurine dosing in children with acute lymphoblastic leukemia.
|
21344614 |
2011 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Thiopurine S-methyltransferase gene polymorphism and 6-mercaptopurine dose intensity in Indian children with acute lymphoblastic leukemia.
|
20153897 |
2010 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Thiopurine S-methyltransferase (TPMT) catalyzes the methylation, and thus deactivation, of 6-mercaptopurine, a thiopurine used in the treatment of acute lymphoblastic leukemia.
|
19663675 |
2009 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Thiopurine S-methyltransferase (TPMT) gene polymorphism in Brazilian children with acute lymphoblastic leukemia: association with clinical and laboratory data.
|
19057372 |
2008 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Thiopurine S-methyltransferase (TPMT) gene polymorphism in Brazilian children with acute lymphoblastic leukemia: association with clinical and laboratory data.
|
19057372 |
2008 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
The low frequency of defective TPMT alleles in Turkish population: a study on pediatric patients with acute lymphoblastic leukemia.
|
17617792 |
2007 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The low frequency of defective TPMT alleles in Turkish population: a study on pediatric patients with acute lymphoblastic leukemia.
|
17617792 |
2007 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Cost-effectiveness of pharmacogenomics in clinical practice: a case study of thiopurine methyltransferase genotyping in acute lymphoblastic leukemia in Europe.
|
16886902 |
2006 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The thiopurine methyltransferase genetic polymorphism is associated with thioguanine-related veno-occlusive disease of the liver in children with acute lymphoblastic leukemia.
|
17015055 |
2006 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia.
|
15784872 |
2005 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Thiopurine methyltransferase polymorphisms in a multiracial asian population and children with acute lymphoblastic leukemia.
|
12142782 |
2002 |