TPMT, thiopurine S-methyltransferase, 7172

N. diseases: 83; N. variants: 5
Disease: Autoimmune hepatitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4721555
Disease: Autoimmune hepatitis
Autoimmune hepatitis 		0.040 Biomarker disease BEFREE The aim of this study was to investigate the influence of <i>NUDT15 R139C</i> and thiopurine S-methyltransferase (<i>TPMT</i>) on azathioprine (AZA) induced leukopenia in patients with autoimmune hepatitis (AIH) and related cirrhosis. 31024313 2019
CUI: C4721555
Disease: Autoimmune hepatitis
Autoimmune hepatitis 		0.040 GeneticVariation disease BEFREE TPMT*3C variants are more frequent in patients with AIH or PBC than in patients with viral hepatitis or healthy volunteers in Japan. 17241387 2007
CUI: C4721555
Disease: Autoimmune hepatitis
Autoimmune hepatitis 		0.040 GeneticVariation disease BEFREE Advanced fibrosis but not TPMT genotype or activity predicts azathioprine toxicity in AIH. 16876902 2006
CUI: C4721555
Disease: Autoimmune hepatitis
Autoimmune hepatitis 		0.040 Biomarker disease BEFREE TPMT phenotyping or genotyping may be advisable before institution of azathioprine therapy in AIH but neither approach invariably predicts response to the drug. 12217596 2002