|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Thyroglobulin antibody (TG-Ab) and thyroid peroxidase antibody (TPO-Ab) are cornerstone biomarkers for autoimmune thyroid diseases, and establishment of appropriate thresholds is crucial for physicians to appropriately interpret test results.
|
31476287 |
2019 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Thyroid peroxidase as a dual active site enzyme: Focus on biosynthesis, hormonogenesis and thyroid disorders of autoimmunity and cancer.
|
30742860 |
2019 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Meta-analysis of studies eligible for quantitative synthesis was performed to estimate pooled odds ratios of thyroid antibodies; thyroid peroxidase antibody (TPO-Ab) and thyroglobulin antibody (TG-Ab), diagnosed thyroid diseases and serological thyroid dysfunctions.
|
31197884 |
2019 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The disorder is usually related to thyroid disease and the most frequent feature is the presence of anti-thyroperoxidase antibodies.
|
31313264 |
2019 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The global methylation levels of B cells were negatively correlated with the serum thyroid peroxidase antibodies in patients with autoimmune thyroid diseases.
|
29336230 |
2018 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Screening for thyroid disorders in pregnancy should include assessment of both TSH and TPOAb, regardless of the screening approach.
|
28102101 |
2017 |
|
Thyroid Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Follow up assessments were conducted every 3 yrs, after which incidence of TD was calculated and its correlations with age, sex, smoking, blood pressure, body mass index (BMI), thyroid peroxidase antibody (TPOAb), thyrotropin (TSH), insulin resistance index, triglycerides and cholesterol were assessed.
|
28972979 |
2017 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Comparison of thyroglobulin and thyroid peroxidase antibodies measured by five different kits in autoimmune thyroid diseases.
|
28768936 |
2017 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We have recently shown that thyroperoxidase antibody positivity impairs the thyroidal response to hCG stimulation, which may suggest that this is a mechanism through which thyroid autoimmunity acts as a risk factor for thyroid disease.
|
28049387 |
2017 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The main outcomes were TPOAb concentrations and positivity, thyroid hormone concentrations (TSH, free T4), and clinical thyroid diseases (subclinical and overt hypothyroidism and goiter).
|
25719932 |
2015 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The presence of TPO antibodies (25.2%) and thyroid disease (8.4%) was associated with older age, female sex, and presence of other autoantibodies (GAD65, ATPase, 21-OH) (all P<0.001).
|
26405068 |
2015 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease.
|
24586183 |
2014 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Cross-reactivity to all 7 linear epitopes encoding homologous amino acid sequences shared by the HCV polyprotein, CYP2D6 (the LKM1 autoantigen), and thyroperoxidase was detected in 86% LKM1-positive HCV patients with clinical thyroid disorders, but in none of the LKM1-positive or negative HCV patients without thyroid disease, and none of an HCV-negative control group comprising subjects with LKM1-positive autoimmune hepatitis or AITD without liver disease ( P < .0001).
|
15952102 |
2005 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The upregulation of both the number and the matured functions of DCs, may lead to present more antigens and to produce more auto-antibodies (such as Tg-Ab and TPO-Ab in HT, TR-Ab in GD), which may be involved in pathogenesis of the autoimmune thyroid diseases.
|
16285898 |
2004 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Biosynthesis of thyroid hormones is an oxidative process that generates reactive oxygen species (ROS) and involves thyroperoxidase (TPO) that is one of the main autoantigens involved in autoimmune thyroid diseases.
|
12960013 |
2003 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
LHGDN |
Identification of the IDR could lead to improved diagnosis of thyroid autoimmune diseases by engineering "mini-TPO" as a target autoantigen or designing therapeutic peptides able to block undesired autoimmune responses.
|
12501244 |
2003 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Positivity in TPO-RT-PCR correlates significantly with metastatic disease in cancer patients and with the presence of thyroid disease in general.
|
12459031 |
2002 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The human anti-thyroid peroxidase autoantibody repertoire in Graves' and Hashimoto's autoimmune thyroid diseases.
|
12073143 |
2002 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
LHGDN |
Positivity in TPO-RT-PCR correlates significantly with metastatic disease in cancer patients and with the presence of thyroid disease in general.
|
12459031 |
2002 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Detection of mRNA transcripts for thyroglobulin (TG), thyroid peroxidase (TPO) and RET/PTC1 in the peripheral blood of patients with thyroid disease.
|
9508203 |
1998 |
|
Thyroid Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To re-evaluate TPO expression in thyroid cancer, TPO mRNA expression was compared with TPO protein expression in 38 samples of thyroid tissue obtained from patients with various thyroid diseases.
|
8691351 |
1996 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Large quantities of pure TPO are essential for understanding its structure and role in normal thyroid function and thyroid diseases.
|
8864829 |
1996 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
A band at approximately 110 kDa characteristic of hTPO was detected in EBVL infected with Ad5-TPO. hTPO expression in EBVL induced with adenovirus should facilitate understanding of T cell immunity to TPO in patients with autoimmune thyroid diseases.
|
8777380 |
1996 |
|
Thyroid Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Thyroperoxidase microsatellite polymorphism in thyroid diseases.
|
8808096 |
1995 |
|
Thyroid Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Over the past 20 years, recombinant deoxyribonucleic acid technology has led to the cloning of three major thyroid specific protein genes (thyroglobulin, thyroperoxidase and thyrotrophin receptor), which happen to be also the main thyroid autoantigens implicated in thyroid diseases.
|
8124482 |
1994 |