|
Acute monoblastic leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We report a case of acute myeloid leukemia (AML) [FAB-M5a] showing a deletion of the short arm of chromosome 2 at band p23 as a sole abnormality in the bone marrow cells.
|
12034535 |
2002 |
|
Adenocarcinoma of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results imply that TCTP might play at least a partial role in colon adenocarcinoma progression.
|
19621893 |
2010 |
|
Adenocarcinoma of lung (disorder)
|
0.030 |
Biomarker
|
disease |
BEFREE |
In this study, we generated several green fluorescent protein (GFP)-tagged TCTP fusion proteins by conjugating a single PTD or tandem PTDs at the N-terminus, the C-terminus, and both termini and compared their transduction efficiencies in human lung adenocarcinoma A549 cells to determine whether the protein transducing function of TCTP depends on the location or the number of PTD moieties in the TCTP molecule.
|
23256924 |
2013 |
|
Adenocarcinoma of lung (disorder)
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In vitro analyses of BT-474 human breast carcinoma and A549 human lung adenocarcinoma cell lines revealed dose-dependent decreases in intracellular ATP levels by DHA treatment, resulting in a significant reduction of Hsp90 and p23 association in both cell lines.
|
27880046 |
2017 |
|
Adenocarcinoma of lung (disorder)
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Then, 24 surgically removed fresh lung adenocarcinoma tissue samples and paired paracancer tissue samples were used to analyze the correlation between TCTP expression and tumor stage by immunohistochemical analysis.
|
30881019 |
2019 |
|
ADENOMAS AND ADENOCARCINOMAS
|
0.010 |
AlteredExpression
|
group |
BEFREE |
1.TCTP levels are significantly increased in colon adenomas and adenocarcinomas, compared to normal colon tissue.2.
|
28143584 |
2017 |
|
Adult Fibrosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Normal p23 protein was detected in the human fibrosarcoma cell line HT1080 by immunoprecipitation with rabbit antibodies raised against an E. coli-expressed R-ras fusion protein.
|
3313005 |
1987 |
|
Adult Liver Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TCTP mRNA transcript increased significantly in liver cancer tissues when compared to non-cancerous adjacent tissues as control.
|
18630514 |
2008 |
|
Advanced breast cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Notably, phospho-TCTP expression levels increase in trastuzumab-resistant breast tumors, suggesting a possible role of phospho-TCTP as a new prognostic marker.In conclusion, the anti-tumor effect of DHA in vitro with conventional chemotherapeutics suggests a novel therapeutic strategy and identifies phospho-TCTP as a new promising target for advanced breast cancer.
|
25779659 |
2015 |
|
Allergy to eggs
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Consistent with these data, patients with egg allergy had higher blood levels of HRF-reactive IgE compared with individuals that were not hypersensitive.
|
29130935 |
2017 |
|
Alzheimer's Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the steady-state p23 levels are reduced in the brains of individuals with AD.
|
18652896 |
2008 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
While patients with severe AD did display a consistent reduction in p23 levels, our inability to observe p19 in mouse or human AD brain samples suggests that the usefulness of the p23 neo-epitope antibody is restricted to cells and primary neurons undergoing cellular stress.
|
21691801 |
2012 |
|
Alzheimer's Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Real-time PCR found that the expression of the histamine-releasing factor gene, known to be associated with cognitive deficits in Alzheimer's disease, was significantly reduced by 19%.
|
12872291 |
2003 |
|
Aortic Valve Insufficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we further characterise p23 roles in AR signalling and show that it modulates cytosolic AR levels in the absence of hormone, confirming a chaperoning function in the aporeceptor complex and suggesting p23 upregulates AR signalling at multiple stages.
|
25241147 |
2015 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Further translational research could prove fortilin to be a viable molecular target for treatment of various human diseases including and not limited to atherosclerosis, hypertension, certain tumors, diabetes mellitus, diabetic nephropathy, hepatic injury, and aberrant immunity and host defense.
|
28939212 |
2019 |
|
Asthma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Peptides or recombinant proteins that block the interactions between HRF and IgE have emerged as promising anti-allergic therapeutics, as administration of them prevented or ameliorated type 2 inflammation in animal models of allergic diseases such as asthma and food allergy.
|
31779161 |
2019 |
|
Asthma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Furthermore, it appears that patients reactive to TCTP have a higher probability to suffer from asthma than other allergic patients.
|
17645945 |
2008 |
|
Asthma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Histamine-releasing factor (HRF) is reported to have a proinflammatory role in asthma and immediate hypersensitivity of the skin.
|
28219065 |
2017 |
|
Asthma
|
0.040 |
Biomarker
|
disease |
LHGDN |
The results do not support the hypothesis that IgE(mn+) induces a LAR, but do not exclude the alternative hypothesis that HRFs are released during a LAR and contribute to asthma severity.
|
12487227 |
2002 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Further translational research could prove fortilin to be a viable molecular target for treatment of various human diseases including and not limited to atherosclerosis, hypertension, certain tumors, diabetes mellitus, diabetic nephropathy, hepatic injury, and aberrant immunity and host defense.
|
28939212 |
2019 |
|
B-Cell Lymphomas
|
0.010 |
Biomarker
|
group |
BEFREE |
Finally, we further demonstrated that miR-1235-3p could restrain the expression levels of TPT1, Pim-3, phosphate-Bcl-2-associated death promoter (p-BAD) and B-cell lymphoma-extra large (Bcl-XL) in A549/DDP cells, while the inhibition could be reversed by pcDNA3.1-TPT1 as well.
|
30805558 |
2018 |
|
Bilateral cataracts (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the current study, we confirmed the role of TCTP in causing intracellular calcium mobilization by inhibiting Na,K-ATPase in a human lens epithelial cell line and further showed that some of the TCTP-transgenic mice develop cataracts with an incidence rate of 7.38% compared to 1.47% in controls.
|
19479337 |
2009 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
TPT1/TCTP is a highly significant prognostic factor in breast cancer.
|
23165143 |
2013 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
This makes p23 an attractive target for combating tumor cell metastasis in breast cancer patients.
|
22074947 |
2012 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Furthermore, the antisense depletion of fortilin from breast cancer cell line MCF-7 was associated with massive cell death.
|
11598139 |
2001 |