|
Fibrosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Normal p23 protein was detected in the human fibrosarcoma cell line HT1080 by immunoprecipitation with rabbit antibodies raised against an E. coli-expressed R-ras fusion protein.
|
3313005 |
1987 |
|
Adult Fibrosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Normal p23 protein was detected in the human fibrosarcoma cell line HT1080 by immunoprecipitation with rabbit antibodies raised against an E. coli-expressed R-ras fusion protein.
|
3313005 |
1987 |
|
Leukemia, Myelocytic, Acute
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We report a case of acute myeloid leukemia (M5a of the FAB classification), secondary to the myelodysplastic syndrome, showing a deletion of the short arm of chromosome 2 at p23 in the bone marrow cells.
|
8500100 |
1993 |
|
Lyme Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
An immunoglobulin M enzyme-linked immunosorbent assay using recombinant OspC as the target antigen shows promise for the serodiagnosis of early stages of Lyme disease.
|
8225587 |
1993 |
|
Fibrolamellar Hepatocellular Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
This cis element binds a protein complex referred to as HRF (heme-responsive factor), which is greatly enhanced both in heme-treated FLCs and during monocyte-to-macrophage differentiation.
|
9032265 |
1997 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our data imply that the TCTP is a housekeeping gene and that its deregulation may be involved in the tumor development of colon carcinoma.
|
10880768 |
2000 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In order to identify genes associated with distinct stages of mammary carcinoma we have investigated the transcriptional profile of normal mammary gland epithelial cells, cell lines derived from primary tumors, from bone marrow micrometastases and from ascites fluid. mRNA's for ribosomal protein L41 and URIM (Up-Regulated In Metastasis) were consistently increased in all cells derived from metastatic lesions. mRNA for human secreted frizzled-related protein (hsFRP) was found to be dramatically down-regulated in all mammary tumor cells compared to non-transformed mammary gland epithelial cells. mRNA for Human Hypoxia Related Factor--2 (HRF-2) and a transcript including the human mitochondrial control region were significantly overexpressed in the cell lines derived from primary tumors and ascites fluid.
|
10953283 |
2000 |
|
Malignant tumor of colon
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Expression of translationally controlled tumor protein mRNA in human colon cancer.
|
10880768 |
2000 |
|
Colon Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our data imply that the TCTP is a housekeeping gene and that its deregulation may be involved in the tumor development of colon carcinoma.
|
10880768 |
2000 |
|
Malignant neoplasm of breast
|
0.090 |
Biomarker
|
disease |
BEFREE |
Furthermore, the antisense depletion of fortilin from breast cancer cell line MCF-7 was associated with massive cell death.
|
11598139 |
2001 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Furthermore, the antisense depletion of fortilin from breast cancer cell line MCF-7 was associated with massive cell death.
|
11598139 |
2001 |
|
Cholestasis of pregnancy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Carriership of long-chain 3-hydroxyacyl-coenzyme A dehydrogenase (LCHAD) deficiency has been reported to be associated with an increased risk of obstetric cholestasis and the gene is located in the p23 region of chromosome 2.
|
11444477 |
2001 |
|
Ductal Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunocytochemistry using HeLa cells transiently expressing FLAG-tagged fortilin and immunohistochemistry using human breast ductal carcinoma tissue and anti-fortilin antibody both showed that fortilin is predominantly localized in the nucleus.
|
11598139 |
2001 |
|
Malignant neoplasm of prostate
|
0.350 |
Biomarker
|
disease |
BEFREE |
The 8p22 through p23 region has been identified as a potential site for genes associated with prostate cancer.
|
12377406 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The gene LZTS1 has been mapped to the 8p22 through p23 region and identified as a potential tumor suppressor based on loss of heterozygosity studies using primary esophageal tumors.
|
12377406 |
2002 |
|
Prostate carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
The 8p22 through p23 region has been identified as a potential site for genes associated with prostate cancer.
|
12377406 |
2002 |
|
Asthma
|
0.040 |
Biomarker
|
disease |
LHGDN |
The results do not support the hypothesis that IgE(mn+) induces a LAR, but do not exclude the alternative hypothesis that HRFs are released during a LAR and contribute to asthma severity.
|
12487227 |
2002 |
|
Leukemia, Myelocytic, Acute
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We report a case of acute myeloid leukemia (AML) [FAB-M5a] showing a deletion of the short arm of chromosome 2 at band p23 as a sole abnormality in the bone marrow cells.
|
12034535 |
2002 |
|
Esophageal Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The gene LZTS1 has been mapped to the 8p22 through p23 region and identified as a potential tumor suppressor based on loss of heterozygosity studies using primary esophageal tumors.
|
12377406 |
2002 |
|
leukemia
|
0.010 |
Biomarker
|
disease |
LHGDN |
Physical and functional interaction between myeloid cell leukemia 1 protein (MCL1) and Fortilin. The potential role of MCL1 as a fortilin chaperone.
|
12149273 |
2002 |
|
Acute monoblastic leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We report a case of acute myeloid leukemia (AML) [FAB-M5a] showing a deletion of the short arm of chromosome 2 at band p23 as a sole abnormality in the bone marrow cells.
|
12034535 |
2002 |
|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
PSYGENET |
The change in expression of the histamine-releasing factor gene suggests that this gene may be associated with the negative symptoms of impaired learning and memory in schizophrenia.
|
12872291 |
2003 |
|
Schizophrenia
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
The change in expression of the histamine-releasing factor gene suggests that this gene may be associated with the negative symptoms of impaired learning and memory in schizophrenia.
|
12872291 |
2003 |
|
Alzheimer's Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Real-time PCR found that the expression of the histamine-releasing factor gene, known to be associated with cognitive deficits in Alzheimer's disease, was significantly reduced by 19%.
|
12872291 |
2003 |
|
Hepatitis C
|
0.020 |
Biomarker
|
disease |
BEFREE |
The core protein of hepatitis C virus (HCV), constructing the viral particle, is processed from its precursor polyprotein and observed as two forms, p23 and p21.
|
12526046 |
2003 |