Serum complement C3 was measured, and endogenous β-cell function was evaluated by area under the C-peptide curve (AUC<sub>cp</sub>) during an oral glucose tolerance test (OGTT) in 411 patients with T2D at baseline from 2011 to 2015.
Fibrin network density increased Δ 1.15 ± 0.28 fibers/μm<sup>2</sup> at day 7 after the hypoglycemic clamp (<i>P</i> < 0.01 for glycemic arm), whereas fibrinogen and complement C3 increased after hypoglycemia up to day 7 in type 2 diabetes only.
There were depot-specific differences in expression of serum T2D predictors: VAT expressed higher levels of complement C3; SAT expressed higher levels of retinol-binding protein-4 (RBP4), adiponectin, and leptin.