|
Bipolar Disorder
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
A haplotype of GRP94, protective against BD, exhibited significantly higher GRP94 expression upon ER stress.
|
18771604 |
2009 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
These results suggest that the therapeutic effects of valproate in bipolar disorder may be mediated by WFS1 expression and its dissociation from GRP94.
|
19125190 |
2009 |
|
Bipolar Disorder
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that the therapeutic effects of valproate in bipolar disorder may be mediated by WFS1 expression and its dissociation from GRP94.
|
19125190 |
2009 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
A haplotype of GRP94, protective against BD, exhibited significantly higher GRP94 expression upon ER stress.
|
18771604 |
2009 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
HSP90B1 may have a pathophysiological role in bipolar disorder in the Japanese population, though further study will be needed to understand the underlying functional mechanisms.
|
17805476 |
2007 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
BEFREE |
HSP90B1 may have a pathophysiological role in bipolar disorder in the Japanese population, though further study will be needed to understand the underlying functional mechanisms.
|
17805476 |
2007 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
LHGDN |
HSP90B1 may have a pathophysiological role in bipolar disorder in the Japanese population, though further study will be needed to understand the underlying functional mechanisms.
|
17805476 |
2007 |
|
Prostatic Neoplasms
|
0.310 |
Biomarker
|
group |
LHGDN |
Decreased adhesiveness, resistance to anoikis and suppression of GRP94 are integral to the survival of circulating tumor cells in prostate cancer.
|
18340425 |
2008 |
|
Prostatic Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
Proteome analysis of human androgen-independent prostate cancer cell lines: variable metastatic potentials correlated with vimentin expression.
|
17566973 |
2007 |
|
Malignant neoplasm of prostate
|
0.300 |
Biomarker
|
disease |
CTD_human |
Proteome analysis of human androgen-independent prostate cancer cell lines: variable metastatic potentials correlated with vimentin expression.
|
17566973 |
2007 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, modulation of Grp94 expression will be discussed as a potential therapeutic goal looking for a decrease in cancer relapses.
|
30981878 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Specifically, over-expression of GRP94 predicts brain metastasis in breast carcinoma patients with either triple negative or ErbB2 positive tumors.
|
31637425 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In both transplantable melanoma and lung carcinoma mice models, immunization with placental gp96-stimulated BMDCs led to a significant decrease in tumor growth and mouse mortality with respect to mice treated with liver gp96-pulsed BMDCs or placental gp96 alone.
|
30703157 |
2019 |
|
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, modulation of Grp94 expression will be discussed as a potential therapeutic goal looking for a decrease in cancer relapses.
|
30981878 |
2019 |
|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
All normal liver tissue exhibited low gp96 expression, whereas high gp96 expression was present in 54% of HCC tissues.
|
30529751 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
As the endoplasmic reticulum paralogue of Hsp90, Grp94 chaperones a small set of client proteins associated with some diseases, including cancer, primary open-angle glaucoma, and inflammatory disorders.
|
30351001 |
2018 |
|
Neoplasm Metastasis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The tissue array results indicated that higher GRP94 expression levels were associated with lower overall survival and higher lympho-node metastasis.
|
29507700 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We previously suggested that Grp94 overexpression is involved in tumor aggressiveness.
|
29852388 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings suggest that Grp94 might act as a potential biomarker for prognosis of canine mammary tumors and monitoring its therapy.
|
28801701 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, miRNAs have been involved in the carcinogenesis and chemoresistance of OS; of them, miR-223 has been reported to be underexpressed and serve as a tumor suppressor in OS through targeting Hsp90B1, also a member of HSP family.
|
29432736 |
2018 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
As the endoplasmic reticulum paralogue of Hsp90, Grp94 chaperones a small set of client proteins associated with some diseases, including cancer, primary open-angle glaucoma, and inflammatory disorders.
|
30351001 |
2018 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our study defines a CD91-dependent mechanism through which gp96 controls dichotomous immune responses relevant to the therapy of cancer and autoimmunity.
|
28561043 |
2017 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Injection of the plasma prevented growth of the tumor cells in immunodeficient mice, whereas plasma IgG depleted of GRP94 IgG exhibited reduced killing activity against cancer cells <i>in vitro</i> These results indicate that humoral immunity, including autoantibodies against GRP94, plays a role in cancer immune surveillance.<i>Cancer Res; 77(21); 6001-10.©2017 AACR</i>.
|
28882998 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Transplantation of iPS-Derived Tumor Cells with a Homozygous MHC Haplotype Induces GRP94 Antibody Production in MHC-Matched Macaques.
|
28882998 |
2017 |