Disease: Metastatic malignant neoplasm to brain ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0220650
Disease: Metastatic malignant neoplasm to brain
Metastatic malignant neoplasm to brain 		0.050 Biomarker disease BEFREE Previous studies have shown a critical role of GRP94 in brain metastasis (BrM) pathogenesis and progression. 31578452 2019
CUI: C0220650
Disease: Metastatic malignant neoplasm to brain
Metastatic malignant neoplasm to brain 		0.050 Biomarker disease BEFREE In conclusion, GRP94 is required for the metabolic stress survival of BrM cells, and it might act as a modulator of lipid metabolism to favor BrM progression. 31395819 2019
CUI: C0220650
Disease: Metastatic malignant neoplasm to brain
Metastatic malignant neoplasm to brain 		0.050 Biomarker disease BEFREE GRP94 ablation was performed in a BrM model BR-eGFP-CMV/Luc-V5CA1 (BRV5CA1) of breast cancer. 31637425 2019
CUI: C0220650
Disease: Metastatic malignant neoplasm to brain
Metastatic malignant neoplasm to brain 		0.050 GeneticVariation disease BEFREE In these patients, GRP94 overexpression also increased the risk of BrM (HR = 3.58; 95% CI: 0.98-13.11; <i>p</i> = 0.054-Wald test). 29250484 2017
CUI: C0220650
Disease: Metastatic malignant neoplasm to brain
Metastatic malignant neoplasm to brain 		0.050 Biomarker disease BEFREE In conclusion our results indicate that FN14 and GRP94 are prediction/prognosis markers which open up new possibilities for preventing/treating brain metastasis. 26497551 2015