TRAF3, TNF receptor associated factor 3, 7187

N. diseases: 129; N. variants: 15
Disease: Osteoporosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.020 Biomarker disease BEFREE Mice with TRAF3 deleted in MPCs develop early onset osteoporosis due to reduced bone formation and enhanced bone destruction. 31243287 2019
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.020 Biomarker disease BEFREE Mice genetically engineered to have TRAF3 deleted in osteoclast precursors and macrophages develop early onset osteoporosis, inflammation in multiple tissues, infections, and tumors, indicating that TRAF3 suppresses inflammation and tumors in myeloid cells. 30323820 2018