TRAF6, TNF receptor associated factor 6, 7189

N. diseases: 254; N. variants: 10
Disease: Arteriosclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.060 Biomarker disease BEFREE Small molecule inhibitors of CD40-TRAF6 have shown to be effective in multiple animal-models of chronic inflammatory disease, such as obesity and atherosclerosis. 30612848 2019
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.060 Biomarker disease BEFREE Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis. 29406859 2018
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.060 Biomarker disease BEFREE In this review, we explore the emerging role of tumor necrosis factor receptor-associated factor 6 (TRAF6)-nuclear factor kappa B (NF-κB) signaling axis in atherosclerosis, ischemic heart disease, pathologic cardiac hypertrophy or heart failure, myocarditis, and sepsis-induced cardiomyopathy. 29175266 2018
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.060 Biomarker disease BEFREE Targeting TRAF6 may delay progression of vascular diseases during diabetes mellitus and atherosclerosis. 30017935 2018
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.060 Biomarker disease BEFREE Blockade of 146b-5p promotes inflammation in atherosclerosis-associated foam cell formation by targeting TRAF6. 29201219 2017
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.060 Biomarker disease BEFREE This study investigated the role of TRAF6-deficiency in mice developing atherosclerosis, a chronic inflammatory disease. 20644648 2010