Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study for the first time ever demonstrated an association between a genetic variant of TRAF6 and low BMD among patients with RA.
|
30506403 |
2019 |
Rheumatoid Arthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Hence, the first-in-class TRAF6-Ubc13 inhibitor C25-140 expands the toolbox for studying the impact of the ubiquitin system on immune signaling and underscores the importance of TRAF6 E3 ligase activity in psoriasis and rheumatoid arthritis.
|
29950522 |
2018 |
Rheumatoid Arthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of NOD2 gene expression significantly decreased NF-κB, TRAF6, and IKK levels, but not caspase-1 levels, in RA FLS.
|
28240593 |
2017 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
TRAF6 in RA-FLSs was inhibited using Lentiviral-TRAF6-shRNA transfection.
|
28506571 |
2017 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
These results support a role for TRAF6 in the pathogenesis of RA, and suggest that the TRAF6 blockade may be a potential strategy in the management of RA.
|
25522907 |
2015 |
Rheumatoid Arthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
SIN effectively inhibited MyD88 and TRAF-6 expression in RA-FLS, which may be one of the important molecular mechanisms involved in RA treatment and prevention of cartilage and subchondral bone destruction.
|
26782542 |
2015 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Therefore, we investigated whether genetic variants in OPG, RANK, RANKL and TRAF6 are associated with the rate of joint destruction in RA.
|
24886600 |
2014 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We evaluated whether a single-nucleotide polymorphism (SNP) of the TRAF6 gene previously associated with systemic lupus erythematosus and rheumatoid arthritis may be a common risk factor for systemic sclerosis (SSc) and giant cell arteritis (GCA).
|
22589256 |
2012 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
CTD_human |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our data indicate the presence of association of TRAF6 with SLE, consistent with the previous report of association with RA.
|
22231568 |
2012 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
As a result, five shared risk feature genes, CD80, EGFR, FN1, GSK3B and TRAF6 were found and proven to be associated with rheumatoid arthritis by previous reports.
|
21910999 |
2011 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
|
20453842 |
2010 |
Rheumatoid Arthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In addition, two targets of miR-146a, namely tumor necrosis factor receptor-associated factor 6 (TRAF6) and IL-1 receptor-associated kinase 1 (IRAK-1), were similarly expressed between rheumatoid arthritis patients and control individuals, despite increased expression of miR-146a in patients with rheumatoid arthritis.
|
18759964 |
2008 |