TRAF6, TNF receptor associated factor 6, 7189

N. diseases: 254; N. variants: 10
Disease: Encephalomyelitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis 		0.020 Biomarker disease BEFREE As CD40-TRAF6 interactions predominantly occur in macrophages, we subjected CD40<sup>flfl</sup> LysM<sup>cre</sup> mice to EAE. 30471110 2019
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis 		0.020 Biomarker disease BEFREE Together, our results indicate that SMI-mediated inhibition of the CD40-TRAF6 pathway skews human monocytes towards anti-inflammatory cells with reduced trans-endothelial migration capacity, and is able to reduce CNS-infiltrated monocyte-derived macrophages during neuro-inflammation, but minimally ameliorates EAE disease severity. 28494768 2017