TSC2, TSC complex subunit 2, 7249

N. diseases: 72; N. variants: 287
Disease: Kidney Neoplasm ×
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0022665
Disease: Kidney Neoplasm
Kidney Neoplasm 		0.400 Biomarker disease CTD_human Renal tumors derived from 2,3,5-tris-(glutathion-S-yl)hydroquinone (TGHQ)-treated Tsc-2(EK/+) rats, and null for tuberin, display elevated nuclear and cytosolic p27, with parallel increases in cytosolic cyclin D1 levels. 21693435 2011
CUI: C0022665
Disease: Kidney Neoplasm
Kidney Neoplasm 		0.400 Biomarker disease CTD_human High extracellular signal-regulated kinase (ERK) activity occurred in the OSOM of Tsc2(EK/+) rats at 4 mo and in TGHQ-induced renal tumors. 12110509 2002
CUI: C0022665
Disease: Kidney Neoplasm
Kidney Neoplasm 		0.400 Biomarker disease CTD_human "Carcinogenicity of a nephrotoxic metabolite of the ""nongenotoxic"" carcinogen hydroquinone." 11170505 2001