C5, complement C5, 727

N. diseases: 129; N. variants: 20
Disease: Asthma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma 		0.230 GeneticVariation disease BEFREE To determine whether genetic variations in the genes of the complement system affect susceptibility to BA, we screened single nucleotide polymorphisms (SNPs) in C3, C5, the C3a receptor gene (C3AR1), and the C5a receptor gene (C5R1) and performed association studies in the Japanese population. 15278436 2004
CUI: C0004096
Disease: Asthma
Asthma 		0.230 Biomarker disease BEFREE Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma. 11160252 2001
CUI: C0004096
Disease: Asthma
Asthma 		0.230 Biomarker disease RGD Contribution of anaphylatoxin C5a to late airway responses after repeated exposure of antigen to allergic rats. 11591795 2001
CUI: C0004096
Disease: Asthma
Asthma 		0.230 Biomarker disease BEFREE Blockade of the C5a receptor rendered human monocytes unable to produce IL-12, mimicking blunted IL-12 production by macrophages from C5-deficient mice and providing a mechanism for the regulation of susceptibility to asthma by C5. 10973279 2000