Multivariate analysis revealed that time for AKI to develop (HR = 0.865; 95% CI 0.799-0.937; P < 0.001), low mean arterial pressure (HR = 0.970; 95% CI 0.958-0.981; P < 0.001), low serum prealbumin (HR = 0.924; 95% CI 0.894-0.955; P < 0.001) level, oliguria (HR = 2.261; 95% CI 1.424-3.590; P = 0.001), mechanical ventilation (HR = 1.492; 95% CI 1.047-2.124; P = 0.027), blood urea nitrogen (HR = 1.037; 95% CI 1.025-1.049; P < 0.001) level, magnesium (HR = 2.512; 95% CI 1.243-5.076; P = 0.010) level, and more severe AKI stages (stage 2: HR = 3.709; 95% CI 1.926-7.141; P < 0.001 and stage 3: HR = 5.660; 95% CI 2.990-10.717; P < 0.001) were independent risk factors for 28-day mortality.
Serum prealbumin level <10 mg/dL at the time of AKI diagnosis was associated with a 155% increased death risk ratio (adjusted hazard ratio [HR], 2.55; 95% confidence interval [CI], 1.18 to 5.49; P = 0.02).