|
Pulmonary Fibrosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The MUC5B promoter variant rs5705950, telomerase complex mutations and short telomere lengths are also linked to an increased susceptibility to pulmonary fibrosis in RA and chronic hypersensitivity pneumonitis.
|
31261211 |
2019 |
|
Pulmonary Fibrosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The MUC5B promoter variant rs5705950, telomerase complex mutations and short telomere lengths are also linked to an increased susceptibility to pulmonary fibrosis in RA and chronic hypersensitivity pneumonitis.
|
31365378 |
2019 |
|
Pulmonary Fibrosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Moreover, patients with the MUC5B polymorphism show more severe coughing as MUC5B encodes for the dominant mucin in the honeycomb cysts of IPF patients.
|
30269188 |
2019 |
|
Pulmonary Fibrosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that mucociliary dysfunction might play a causative role in bleomycin-induced pulmonary fibrosis in mice overexpressing Muc5b, and that MUC5B in distal airspaces is a potential therapeutic target in humans with IPF.
|
30560893 |
2018 |
|
Pulmonary Fibrosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The relationship between complement C3 expression and the MUC5B genotype in pulmonary fibrosis.
|
29565179 |
2018 |
|
Pulmonary Fibrosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A single-nucleotide polymorphism (rs35705950) in the mucin 5B (<i>MUC5B</i>) gene promoter is associated with pulmonary fibrosis and interstitial features on chest CT but may also have beneficial effects.
|
29440587 |
2018 |
|
Pulmonary Fibrosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
In FIP, MUC5B minor allele predicts better survival, pointing towards a subgroup of FIP patients with a milder, MUC5B-driven form of pulmonary fibrosis.
|
26699835 |
2016 |
|
Pulmonary Fibrosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We have previously found that 1) a common gain-of-function promoter variant in MUC5B rs35705950 is the strongest risk factor (genetic and otherwise), accounting for 30-35% of the risk of developing IPF, a disease that was previously considered idiopathic; 2) the MUC5B promoter variant can potentially be used to identify individuals with preclinical pulmonary fibrosis and is predictive of radiologic progression of preclinical pulmonary fibrosis; and 3) MUC5B may be involved in the pathogenesis of pulmonary fibrosis with MUC5B message and protein expressed in bronchiolo-alveolar epithelia of IPF and the characteristic IPF honeycomb cysts.
|
27630174 |
2016 |
|
Pulmonary Fibrosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
CT Imaging Phenotypes of Pulmonary Fibrosis in the MUC5B Promoter Site Polymorphism.
|
26836909 |
2016 |
|
Pulmonary Fibrosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Genetic variations have been recognized to be involved in the multi-factorial susceptibility to CWP, and MUC5B is a candidate lung fibrosis susceptibility gene.
|
24924948 |
2014 |
|
Pulmonary Fibrosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
We summarize information on the genetics of pulmonary fibrosis by focusing on the recent genetic findings of MUC5B.
|
24547893 |
2014 |
|
Pulmonary Fibrosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The MUC5B variant was not a risk factor for lung fibrosis in patients with SSc or sarcoidosis and did not predict more rapidly progressive lung disease in any of the groups.
|
23321605 |
2013 |
|
Pulmonary Fibrosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To determine whether the MUC5B promoter polymorphism (rs35705950), previously reported to be associated with the development of pulmonary fibrosis, is associated with survival in IPF.
|
23695349 |
2013 |
|
Pulmonary Fibrosis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggest that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis.
|
21506741 |
2011 |
|
Pulmonary Fibrosis
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|