C5AR1, complement C5a receptor 1, 728

N. diseases: 179; N. variants: 2
Disease: Alzheimer's Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.060 Biomarker disease BEFREE C5aR1 knock out mice were crossed to the Arctic AD mouse model, and characterized for pathology and for behavior performance in a hippocampal dependent memory task. 28923083 2017
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.060 Biomarker disease BEFREE Previous work demonstrated that the C5aR1 antagonist, PMX205, decreased amyloid pathology and suppressed cognitive deficits in two Alzheimer's Disease (AD) mouse models. 28078911 2017
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.060 Biomarker disease BEFREE Antibodies to serotonin receptors [5-HT2AR (effect size (r) = 0.21, p = 0.004), 5-HT2CR (r = 0.25, p = 0.0005) and 5-HT7R (r = 0.21, p = 0.003)], vascular endothelial growth factor receptor 1 [VEGFR1 (r = 0.29, p < 0.001)] and immune-receptors (Stabilin-1 (r = 0.23, p = 0.001) and C5aR1 (r = 0.21, p = 0.004) were higher in AD. 28697567 2017
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.060 Biomarker disease BEFREE Recently, a C5a receptor antagonist was shown to suppress neuropathology in two murine models of AD, Tg2576 and 3xTg. 21235806 2011
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.060 AlteredExpression disease BEFREE To further characterize the role of complement in AD-related neuroinflammation, we examined the age- and disease-associated expression of CD88 in brain of transgenic mouse models of AD and the influence of PMX205 on the presence of various complement activation products using flow cytometry, western blot, and immunohistochemistry. 20132482 2010
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.060 AlteredExpression disease LHGDN Complement C5a receptor-mediated signaling may be involved in neurodegeneration in Alzheimer's disease. 12759460 2003