Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
In breast cancer patients, TWIST1 and PRKD1 expression correlated with metastatic recurrence, particularly in basal breast cancer.
|
31676574 |
2020 |
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Collectively, these findings extend our understanding of AGR2 regulation in breast cancer and may contribute to development of Twist1-AGR2 targeting therapeutics for breast cancer.
|
31202462 |
2019 |
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that miR-186 functions as a tumor suppressor by targeting Twist1 in BC. miR-186 may serve as a novel biomarker in BC diagnosis or a new therapeutic target in BC treatment.
|
30552711 |
2019 |
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
To conclude, NONHSAT101069 was upregulated in BC tissues and promoted epirubicin resistance, migration and invasion of BC cells via regulation of NONHSAT101069/miR-129-5p/Twist1 axis, highlighting its potential as an oncogene and a therapeutic biomarker for BC.
|
31444414 |
2019 |
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Furthermore, the re-expression of an α-parvin mutant in which the G3BP2-binding site is ablated, unlike that of wild-type α-parvin, in α-parvin-deficient breast cancer cells, is unable to restore the level and signaling of TWIST1 and promote breast cancer progression.
|
30804457 |
2019 |
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Association of FOXA1 and EMT markers (Twist1 and E-cadherin) in breast cancer.
|
30941644 |
2019 |
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Subcellular NHERF1 localization, vascular endothelial growth factor (VEGF), its receptor VEGFR1, hypoxia inducible factor 1 alpha (HIF-1α), TWIST1 expression and microvessel density (MVD) in 183 invasive BCs were evaluated, using immunohistochemistry on tissue microarrays (TMA).
|
29716631 |
2018 |
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Notably, we found a positive correlation between SPZ1 and Twist1 in breast cancer samples from patients with anthracycline or taxane-based chemotherapy.
|
30076850 |
2018 |
Breast Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Associations of gene‑wide SNPs in SNAI1 and TWIST1 with breast cancer and ovarian cancer susceptibility among Chinese Han women.
|
30272327 |
2018 |
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
These findings define Twist1 as a major target of lncATB in the induction of the EMT and highlight lncATB as a biomarker in breast cancer patients.
|
30518916 |
2018 |
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
VEGF and TWIST1 in a 16-biomarker immunoprofile useful for prognosis of breast cancer patients.
|
28677228 |
2017 |
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
The present study aimed to explore the role of the combination of Twist1 expression in metastasized ALN and the serum level of CA15‑3 in evaluating the prognosis of patients with breast cancer. cluster of differentiation (CD)44, CD24, aldehyde dehydrogenase (ALDH)1 and Twist1 expression in normal and metastasized ALN from 102 patients with breast cancer were detected using laser confocal microscopy and the expression of the genes evaluated by reverse transcription‑quantitative polymerase chain reaction; E‑cadherin, N‑cadherin and vimentin expression was also tested by western blotting.
|
28112378 |
2017 |
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Establishment of twist-1 and TGFBR2 as direct targets of microRNA-20a in mesenchymal to epithelial transition of breast cancer cell-line MDA-MB-231.
|
28987542 |
2017 |
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
However, the regulatory and functional relationships between Twist1 and Foxa1 in breast cancer progression are unknown.
|
27524420 |
2017 |
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Results showed that co-delivery of miR-34a and TQ is able to inactivate EMT signaling pathway by directly targeting TWIST1 and ZEB1 in BT-549 cell line, indicating that they might be a promising therapeutic combination against breast cancer metastasis.
|
28423483 |
2017 |
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Our data establishes a Twist over-expressing mouse model of breast cancer, which metastasizes to the lung and replicates some of the ontogeny of human breast cancer progression.
|
28086829 |
2017 |
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Studies investigating Twist protein or mRNA expression as well as reporting survival data in breast cancer were included.
|
29016671 |
2017 |
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
To determine the intrinsic role of Twist1 in EMT and breast cancer initiation, growth, and metastasis, we developed mouse models with an oncogene-induced mammary tumor containing wild-type (WT) <i>Twist1</i> or tumor cell-specific <i>Twist1</i> knockout (Twist1<sup>TKO</sup>).
|
29073077 |
2017 |
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
We have aimed to demonstrate the impact of TGF-β1 and fluvastatin on human breast cancer (MCF-7) and human hepatocellular carcinoma (Hep3B) cell cultures via Real-Time Cell Analyzer (RTCA) and to test the expression levels of some genes (NDRG1, SGK1, TWIST1, AMPKA2) and to compare their gene expression levels according to RTCA results.
|
26419593 |
2016 |
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Our findings add to accumulating evidence that microRNAs are involved in breast cancer progression by modulating TWIST1 expression.
|
27930738 |
2016 |
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Breast cancer-specific mortality was higher among obese (BMI ≥ 30) patients with promoter methylation in APC (HR = 2.47; 95 % CI = 1.43-4.27) and TWIST1 (HR = 4.25; 95 % CI = 1.43-12.70) in breast cancer tissue.
|
26945992 |
2016 |
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Importantly, an increase in SCP1 expression in breast cancer cells with either endogenous or ectopically expressed Twist1 largely inhibits the Twist1-induced epithelial-to-mesenchymal transition phenotype and the migration and invasion capabilities of these cells.
|
26975371 |
2016 |
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
We find that TRIM28 is highly expressed in both cancer cell lines and advanced breast cancer tissues, and the levels of TRIM28 and TWIST1 are positively correlated with the aggressiveness of breast carcinomas.
|
27412325 |
2016 |
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Using a tethered dimer strategy, we successively assessed the ability of TWIST1 dimers to cooperate with an activated version of RAS in human mammary epithelial cell transformation, to provide mice with the ability to spontaneously develop breast tumors, and lastly to maintain a senescence program at a latent state in several breast cancer cell lines.
|
27237323 |
2016 |
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Of interest, H2A.X expression level tightly correlates with Twist1, and to a lesser extent with Slug in the panel of human breast cancer cell lines of the NCI-60 datasets.
|
27315462 |
2016 |