TNFSF4, TNF superfamily member 4, 7292

N. diseases: 129; N. variants: 32
Disease: Colitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009319
Disease: Colitis
Colitis 		0.030 AlteredExpression disease BEFREE In contrast to this protective role in acute colitis, TL1A-dependent expression of co-stimulatory molecule OX40L in MHCII<sup>+</sup> ILC3s during colitis led to co-stimulation of antigen-specific T cells that was required for chronic T cell colitis. 30552020 2018
CUI: C0009319
Disease: Colitis
Colitis 		0.030 Biomarker disease BEFREE However, both proteins reduced T cell-mediated colitis in mice to the same extent, indicating that in vivo neutralization of OX40L is sufficient. 12223520 2002
CUI: C0009319
Disease: Colitis
Colitis 		0.030 Biomarker disease BEFREE Administration of the OX40-IgG fusion protein to mice with ongoing colitis (but not the OX40 ligand-IgG) ameliorated disease in both mouse models of inflammatory bowel disease. 9886424 1999