TNFSF4, TNF superfamily member 4, 7292

N. diseases: 129; N. variants: 32
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.020 AlteredExpression disease BEFREE Low expression of TNFSF4 mRNA is associated with worse prognosis in all melanoma patients and in the cohorts of stage III and stage IIIc-IV patients. 31501955 2019
CUI: C0025202
Disease: melanoma
melanoma 		0.020 AlteredExpression disease BEFREE It was presumed that this effect was mediated by changes in DCs and/or T cells.In this issue of the JCI, Zaini et al. report that, in mice, intratumoral injection of DCs genetically modified to express OX40L suppressed the growth of a preexisting melanoma by directly triggering an antitumor NKT cell response (see the related article beginning on page 3330). 17975660 2007