TNFSF4, TNF superfamily member 4, 7292

N. diseases: 129; N. variants: 32
Disease: Systemic Scleroderma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.040 AlteredExpression disease BEFREE CD28, CTLA-4, ICOS, and OX40L are overexpressed in patients with SSc, particularly in patients with cutaneous diffuse forms. 30619351 2018
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.040 GeneticVariation disease BEFREE We confirm TNFSF4 as an SSc susceptibility gene and rs2205960 as a putative causal variant with preferential association in the ACA+ SSc subphenotype. 22422496 2012
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.040 GeneticVariation disease BEFREE A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort. 21187296 2011
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.040 GeneticVariation disease BEFREE Polymorphisms in the TNFSF4 gene region are associated with susceptibility to SSc and its clinical and autoantibody subsets. 19778912 2010