CCR2, C-C motif chemokine receptor 2, 729230

N. diseases: 436; N. variants: 7
Disease: Degenerative polyarthritis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.070 Biomarker disease BEFREE CCR2 upregulated on peripheral T cells in osteoarthritis but not in bone marrow. 30403025 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.070 Biomarker disease BEFREE We found that CCR2+ cells are abundant in human OA synovium and that CCR2+ macrophages line, invade and are associated with the erosion of OA cartilage. 27965260 2017
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.070 Biomarker disease BEFREE We investigated the role of CCL2 and its receptor CCR2 in experimental OA. 27746376 2017
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.070 Biomarker disease BEFREE The results of this study demonstrate that the MCP-1-CCR2 ligand-receptor axis plays a special role in the initiation and progression of OA pathology. 26578310 2015
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.070 Biomarker disease BEFREE These observations suggest a key role for the MCP-1/CCR2 pathway in establishing osteoarthritis pain. 23185004 2012
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.070 Biomarker disease BEFREE Differences between OA and IA samples were present for all receptors but CCR2 and CXCR4. 12509607 2003
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.070 AlteredExpression disease BEFREE The C-C chemokines and their receptors CCR-2 and CCR-5 were found to be expressed in normal and OA chondrocytes. 11352237 2001