|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, we identified putative mRNA targets of miR-125a-5p, including ERBB2, EIF4EBP1, and TXNRD1, which support the tumor suppressive mechanism of miR-125a-5p.
|
31325708 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Administration of the pharmacological TXNRD1 inhibitor auranofin (AUR) effectively suppressed the growth of HCC tumors induced using the hydrodynamic tail vein injection and orthotopic implantation models in vivo.
|
30561826 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Finally, although TrxR1-null and TrxR1/Gsr-null livers showed strong Nrf2 activity in noncancerous hepatocytes, there was no correlation between malignancy and Nrf2 expression within tumors across genotypes.
|
31097586 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
TrxR1 activity in gastric cells or tumor tissues was determined by the endpoint insulin reduction assay.
|
31113439 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
CTD treatment of mice implanted with colon cancer cells showed tumor growth inhibition and reduced TrxR1 activity and ROS level.
|
29037867 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Post-radiotherapy, TIGAR low-expression predicted significant longer survival time for animals suffering from TrxR1-overexpessing xenografts, which suggested that TIGAR abrogation might be a promising strategy for radiosensitizing TrxR1-overexpressing glial tumours.
|
28338004 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
TXNRD1 overexpression rescued tumors from AF-TUSC2-erlotinib induced apoptosis.
|
27845352 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Based on this review it may be concluded that an understanding of the impact of ITC and Se on aberrant DNA methylation in relation to factors modulating gene-specific and global methylation patterns, in addition to the effect of these food constituents as modulators of key selenoenzymes, such as gastrointestinal glutathione peroxidase-2 (GPx2) and thioredoxin reductase-1 (TrxR1), may provide insights into the potential synergy among various components of a plant-based diet that may counteract the genetic and epigenetic alterations that initiate and sustain neoplasia.
|
22391025 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Statins inhibit expression of thioredoxin reductase 1 in rat and human liver and reduce tumour development.
|
22222370 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Interestingly, patients with ERBB2-status-positive tumors expressed higher levels of TXNRD1.
|
20584310 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These results show the critical role of TxnRd1 in curcumin-mediated radiosensitization and suggest that TxnRd1 levels in tumors could have clinical value as a predictor of response to curcumin and radiotherapy.
|
20160040 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
SOD2 and TXNRD1 expression correlated to tumour size and Gleason score.
|
19818074 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Expression array analysis revealed that CA induced an oxidative stress response in A375 cells, up-regulating heme oxygenase 1, sulfiredoxin 1 homolog, thioredoxin reductase 1, and other genes, including the cell-cycle regulator and stress-responsive tumor suppressor gene cyclin-dependent kinase inhibitor 1A, a key mediator of G1-phase arrest.
|
19000754 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The inhibition of TrxR1 can sensitize tumor cells to agents that induce oxidative stress and may directly trigger cell death.
|
19838062 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our data show differential expression of TrxR1 mRNA forms in malignant mesothelioma of different phenotype, and investigation of alternative transcript variants of TrxR1 could be a valuable tool in the diagnostics and characterization of tumors.
|
17316382 |
2007 |