TXNRD1, thioredoxin reductase 1, 7296

N. diseases: 136; N. variants: 21
Disease: Liver carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.070 AlteredExpression disease BEFREE Collectively, we demonstrated that SLC27A5 acts as a novel tumor suppressor by suppressing TXNRD1 expression via the KEAP1/NRF2 pathway in HCC. 31367013 2020
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.070 AlteredExpression disease BEFREE Additionally, TrxR1 is significantly upregulated in existing HCC databases and available HCC clinical specimens. 31680962 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.070 Biomarker disease BEFREE <i>Thioredoxin reductase 1</i> (<i>TXNRD1</i>) is an antioxidant enzyme reportedly overexpressed in hepatocellular carcinoma (HCC); however, the detailed function and mechanisms of TXNRD1 in HCC remain obscure. 31384178 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.070 Biomarker disease BEFREE Administration of the pharmacological TXNRD1 inhibitor auranofin (AUR) effectively suppressed the growth of HCC tumors induced using the hydrodynamic tail vein injection and orthotopic implantation models in vivo. 30561826 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.070 Biomarker disease BEFREE TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy. 31097586 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.070 AlteredExpression disease BEFREE PCK1 Downregulation Promotes TXNRD1 Expression and Hepatoma Cell Growth via the Nrf2/Keap1 Pathway. 30619751 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.070 Biomarker disease BEFREE In conclusion, our data suggested that TXNRD1 was a biomarker for the prognosis of patients with HCC. 28536696 2017