|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here we demonstrate that TYK2 is highly expressed in all cases of human ALCL, and that in a mouse model of NPM-ALK-induced lymphoma, genetic disruption of Tyk2 delays the onset of tumors and prolongs survival of the mice.
|
30131584 |
2019 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Similarly, NK cell-mediated tumor surveillance was unimpaired upon deletion of TYK2 in NK cells only.
|
30718299 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The gene expression profiles revealed that, compared with cancer cells, AMSCs expressed low levels of oncogenes, including <i>MYC</i>, <i>RAS</i> and ErbB receptor tyrosine kinase 2, and high levels of tumor suppressor genes, including RB transcriptional corepressor 1, phosphatase and tensin homolog, and cyclin-dependent kinase inhibitor 2A.
|
28927044 |
2017 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In contrast to the accelerated tumor onset observed in the haploid-insufficient ErbB2 tumors, deletion of both β-catenin alleles in the ErbB2<sup>KI</sup> model had only a minor impact on tumor onset that further correlated with the retention of normal adherens junctions.
|
28096336 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Due to its cytokine signalling functions TYK2 was found to be essential in tumour surveillance.
|
26631911 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Fluorescence in situ hybridization revealed NPM1-TYK2 fusions in 2 of 47 (4%) primary cases of CD30-positive LPDs and was absent in other mature T-cell neoplasms (n = 151).
|
25349176 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tyk2-deficient mice are viable and fertile but display multiple immunological defects, most prominently high sensitivity to infections and defective tumour surveillance.
|
21622231 |
2011 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The c-kit gene mutations are generally confined to the tyrosine kinase II domain in mast cell neoplasms, but are often observed at the juxtamembrane domain in GISTs.
|
17259998 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The cell-autonomous properties of Abelson murine leukemia virus-transformed (A-MuLV-transformed) TYK2(-/-) cells were unaltered, but the high susceptibility of TYK2(-/-) mice resulted from an impaired tumor surveillance, and accordingly, TYK2(-/-) A-MuLV-induced lymphomas were easily rejected after transplantation into WT hosts.
|
15578097 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, while these results add tyk2 to a growing list of interferon-alpha regulated proteins that might be able to suppress tumor formation, the biochemical basis of this activity remains unknown.
|
8642873 |
1996 |