Colorectal Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Mutations were detected at positions 961 and/or 1031 in the 3'-untranslated regions of the TS gene from the metastases; mutations at these sites were also detected in DNA isolated from normal colon mucosa (n=4) and primary colorectal tumors (n=4).
|
11686531 |
2001 |
Colorectal Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Marked variation of thymidylate synthase and folylpolyglutamate synthetase gene expression in human colorectal tumors.
|
10821538 |
1999 |
Colorectal Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Median gene expression levels of TP and TS did not differ significantly between primary colorectal tumor and corresponding lymph node metastasis but median DPD gene expression levels in the lymph node metastases were significantly higher compared to matched primary colorectal tumors (p=0.015).
|
16391809 |
2006 |
Colorectal Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Studies thus far involving colorectal tumors obtained from patients have focused predominantly on the predictive value of levels of TS expression and p53 mutations in determining response to 5-FU.
|
12084458 |
2002 |
Colorectal Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
In 44/45 microdissected tumors the TS enhancer genotype was identical between paired samples of colorectal tumor and normal tissue.
|
11445856 |
2001 |
Colorectal Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
In this study, the mRNA expression levels of these 81 selected genes and the genes of 5-FU-related enzymes, including thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and orotate phosphoribosyltransferase (OPRT), were measured using real-time quantitative RT-PCR assays of surgically resected materials from primary colorectal tumors in 22 patients.
|
16477629 |
2006 |
Colorectal Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
In this study, we investigated the association between both DPD and TS expressions in primary colorectal tumor and the antitumor effect in patients with metastatic colorectal cancer when treated with a fluoropyrimidine-based protocol.
|
12576451 |
2003 |
Colorectal Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
We present a novel, standardized approach for TP, DPD, and TS mRNA quantification in archival tissue specimens and applied this to a large series of primary colorectal tumors.
|
16132996 |
2006 |
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
This trial demonstrated that intratumoral TS/beta-actin messenger RNA (mRNA) ratio can accurately predict which metastatic colorectal tumors will be resistant to a leucovorin-modulated 5-FU infusion and which have a high likelihood of responding to such a regimen.
|
9726090 |
1998 |
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Influence of thymidylate synthase gene polymorphisms on the survival of colorectal cancer patients receiving adjuvant 5-fluorouracil.
|
16141798 |
2005 |
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
[Relationship between expression of thymidylate synthase and colorectal carcinoma].
|
15500737 |
2004 |
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Prognostic significance of numeric aberrations of genes for thymidylate synthase, thymidine phosphorylase and dihydrofolate reductase in colorectal cancer.
|
18607850 |
2008 |
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy.
|
18676755 |
2008 |
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Thymidylate synthase and microsatellite instability in colorectal cancer: implications for disease free survival, treatment response and survival with metastases.
|
17943475 |
2008 |
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Lymph node status and TS gene expression are prognostic markers in stage II/III rectal cancer after neoadjuvant fluorouracil-based chemoradiotherapy.
|
16943523 |
2006 |
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer and normal mucosa in patients.
|
17047489 |
2006 |
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis.
|
19020767 |
2008 |
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Highly Expressed Genes in Rapidly Proliferating Tumor Cells as New Targets for Colorectal Cancer Treatment.
|
25944804 |
2015 |
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
[Thymidylate synthase and dihydropyrimidine dehydrogenase gene expressions in colorectal cancer using the Danenberg tumor profile method].
|
15222106 |
2004 |
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Single nucleotide polymorphism in the 5' tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients.
|
15386371 |
2004 |
Colorectal Neoplasms
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Combination of polymorphisms within 5' and 3' untranslated regions of thymidylate synthase gene modulates survival in 5 fluorouracil-treated colorectal cancer patients.
|
19082493 |
2009 |
Colorectal Neoplasms
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Immunohistochemical analysis of thymidylate synthase, p16(INK4a), cyclin-dependent kinase 4 and cyclin D1 in colorectal cancers receiving preoperative chemotherapy: significance of p16(INK4a)-mediated cellular arrest as an indicator of chemosensitivity to 5-fluorouracil.
|
15260847 |
2004 |
Colorectal Neoplasms
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Clinical implications of thymidylate synthetase, dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase activity levels in colorectal carcinoma following radical resection and administration of adjuvant 5-FU chemotherapy.
|
18597678 |
2008 |
Colorectal Neoplasms
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms and toxicity to capecitabine in advanced colorectal cancer patients.
|
18245544 |
2008 |
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
LHGDN |
Copy-number analysis of topoisomerase and thymidylate synthase genes in frozen and FFPE DNAs of colorectal cancers.
|
18855534 |
2008 |