Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
This trial demonstrated that intratumoral TS/beta-actin messenger RNA (mRNA) ratio can accurately predict which metastatic colorectal tumors will be resistant to a leucovorin-modulated 5-FU infusion and which have a high likelihood of responding to such a regimen.
|
9726090 |
1998 |
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
RGD |
Correlation between histological differentiation and DNA-synthesizing enzymes in rat colorectal tumors induced with 1, 2-dimethylhydrazine.
|
10523711 |
1999 |
Colorectal Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Marked variation of thymidylate synthase and folylpolyglutamate synthetase gene expression in human colorectal tumors.
|
10821538 |
1999 |
Colorectal Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
In 44/45 microdissected tumors the TS enhancer genotype was identical between paired samples of colorectal tumor and normal tissue.
|
11445856 |
2001 |
Colorectal Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Mutations were detected at positions 961 and/or 1031 in the 3'-untranslated regions of the TS gene from the metastases; mutations at these sites were also detected in DNA isolated from normal colon mucosa (n=4) and primary colorectal tumors (n=4).
|
11686531 |
2001 |
Colorectal Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Studies thus far involving colorectal tumors obtained from patients have focused predominantly on the predictive value of levels of TS expression and p53 mutations in determining response to 5-FU.
|
12084458 |
2002 |
Colorectal Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
In this study, we investigated the association between both DPD and TS expressions in primary colorectal tumor and the antitumor effect in patients with metastatic colorectal cancer when treated with a fluoropyrimidine-based protocol.
|
12576451 |
2003 |
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
LHGDN |
DPD and TS expressions were measured by reverse transcription-PCR in surgically resected materials of primary colorectal tumors from 37 patients who went on to receive oral treatment of uracil and tegafur and leucovorin for either synchronous or metachronous metastatic diseases.
|
12576451 |
2003 |
Colorectal Neoplasms
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Thymidylate synthase expression in advanced colorectal cancer predicts for response to raltitrexed.
|
12576452 |
2003 |
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
LHGDN |
Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression levels: predictors for survival in colorectal cancer patients receiving adjuvant 5-fluorouracil.
|
14519634 |
2003 |
Colorectal Neoplasms
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Loss of heterozygosity at the thymidylate synthase (TS) locus on chromosome 18 affects tumor response and survival in individuals heterozygous for a 28-bp polymorphism in the TS gene.
|
14760062 |
2004 |
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
[Thymidylate synthase and dihydropyrimidine dehydrogenase gene expressions in colorectal cancer using the Danenberg tumor profile method].
|
15222106 |
2004 |
Colorectal Neoplasms
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Immunohistochemical analysis of thymidylate synthase, p16(INK4a), cyclin-dependent kinase 4 and cyclin D1 in colorectal cancers receiving preoperative chemotherapy: significance of p16(INK4a)-mediated cellular arrest as an indicator of chemosensitivity to 5-fluorouracil.
|
15260847 |
2004 |
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Single nucleotide polymorphism in the 5' tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients.
|
15386371 |
2004 |
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
[Relationship between expression of thymidylate synthase and colorectal carcinoma].
|
15500737 |
2004 |
Colorectal Neoplasms
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Thymidylate synthase polymorphism and microsatellite instability: association in colorectal cancer.
|
15571262 |
2004 |
Colorectal Neoplasms
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Thymidylate synthase gene promoter polymorphisms are associated with TSmRNA expressions but not with microsatellite instability in colorectal cancer.
|
15736425 |
2005 |
Colorectal Neoplasms
|
0.600 |
AlteredExpression
|
group |
LHGDN |
We present a novel, standardized approach for TP, DPD, and TS mRNA quantification in archival tissue specimens and applied this to a large series of primary colorectal tumors.
|
16132996 |
2006 |
Colorectal Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
We present a novel, standardized approach for TP, DPD, and TS mRNA quantification in archival tissue specimens and applied this to a large series of primary colorectal tumors.
|
16132996 |
2006 |
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Influence of thymidylate synthase gene polymorphisms on the survival of colorectal cancer patients receiving adjuvant 5-fluorouracil.
|
16141798 |
2005 |
Colorectal Neoplasms
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Median gene expression levels of TP and TS did not differ significantly between primary colorectal tumor and corresponding lymph node metastasis but median DPD gene expression levels in the lymph node metastases were significantly higher compared to matched primary colorectal tumors (p=0.015).
|
16391809 |
2006 |
Colorectal Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
In this study, the mRNA expression levels of these 81 selected genes and the genes of 5-FU-related enzymes, including thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and orotate phosphoribosyltransferase (OPRT), were measured using real-time quantitative RT-PCR assays of surgically resected materials from primary colorectal tumors in 22 patients.
|
16477629 |
2006 |
Colorectal Neoplasms
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Thymidylate synthase expression pattern, expression level and single nucleotide polymorphism are predictors for disease-free survival in patients of colorectal cancer treated with 5-fluorouracil.
|
16596248 |
2006 |
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Lymph node status and TS gene expression are prognostic markers in stage II/III rectal cancer after neoadjuvant fluorouracil-based chemoradiotherapy.
|
16943523 |
2006 |
Colorectal Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer and normal mucosa in patients.
|
17047489 |
2006 |