TYMS, thymidylate synthetase, 7298

N. diseases: 406; N. variants: 19
Disease: Neutropenia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027947
Disease: Neutropenia
Neutropenia 		0.030 GeneticVariation disease BEFREE Furthermore, dominant allele carriers of thymidylate synthase 1494 del6 were at a higher risk of developing neutropenia [OR (95% CI) = 6 (1.2-31.1); p = 0.04]. 30684021 2019
CUI: C0027947
Disease: Neutropenia
Neutropenia 		0.030 GeneticVariation disease BEFREE ADK (rs10824095) (P = 0.004, odds ratio [OR] = 6.220), SLC29A1 (rs747199) (P = 0.016, OR = 5.681), and TYMS (rs34743033) (P = 0.045, OR = 3.846) were associated with neutropenia. 26332308 2015
CUI: C0027947
Disease: Neutropenia
Neutropenia 		0.030 GeneticVariation disease BEFREE A significant difference was observed in the time to onset of severe toxicity, defined as grade 4 neutropenia and/or grade 3 to 4 gastrointestinal toxicities according to OPRT and TYMS promoter polymorphisms. 16818689 2006