TYR, tyrosinase, 7299

N. diseases: 281; N. variants: 121
Disease: Chloasma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025218
Disease: Chloasma
Chloasma 		0.040 Biomarker disease BEFREE Therefore, tyrosinase inhibitors are used in cosmetic and medicinal industries to prevent or treat overproduction of melanin such as melasma, solar lentigo and post inflammatory melanoderma. 31089372 2019
CUI: C0025218
Disease: Chloasma
Chloasma 		0.040 Biomarker disease BEFREE To investigate new treatment options, we performed an exploratory double-blinded, randomized split-face study to assess the efficacy of the tyrosinase inhibitor Thiamidol compared to hydroquinone in women with mild to moderate melasma. 30825454 2019
CUI: C0025218
Disease: Chloasma
Chloasma 		0.040 AlteredExpression disease BEFREE Decreasing tyrosinase activity has been targeted for the prevention of conditions related to the hyperpigmentation of the skin, such as melasma and age spots. 30107341 2018
CUI: C0025218
Disease: Chloasma
Chloasma 		0.040 AlteredExpression disease BEFREE A significant association was observed between GPER and TYR expression in chloasma skin lesions relative to normal skin. 27378491 2017