|
Dermatologic disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Tyrosinase is the rate-limiting enzyme for controlling the production of melanin in the human body, and overproduction of melanin can lead to a variety of skin disorders.
|
31614273 |
2020 |
|
Dermatologic disorders
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Many skin disorders and diseases are related to tyrosinase activity, in particular, due to the vital role played by this enzyme in the melanogenic process.
|
31233796 |
2019 |
|
Dermatologic disorders
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Ultraviolet radiation (UVR)-induced redox imbalance in melanocytes triggers the activation of tyrosinase that results in melanogenesis and its related skin disorders.
|
31432056 |
2019 |
|
Dermatologic disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Functional deficiency of tyrosinase results in serious dermatological diseases.
|
31334690 |
2019 |
|
Dermatologic disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Carbazoles and hydrazones are new and emerging classes of compounds as tyrosinase inhibitors that may provide new structural avenues to discovery of drugs targeting the treatment of hyperpigmentation and related dermatological disorders.
|
30384179 |
2019 |
|
Dermatologic disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Kojic monooleate (KMO) is an ester derived from a fungal metabolite of kojic acid with monounsaturated fatty acid, oleic acid, which contains tyrosinase inhibitor to treat skin disorders such as hyperpigmentation.
|
30410332 |
2018 |
|
Dermatologic disorders
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Being a typical copper-containing oxidase, tyrosinase plays critical roles in biological activity, and its aberrant expression might cause diverse skin diseases.
|
30149701 |
2018 |
|
Dermatologic disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
The inhibitors of tyrosinase are important for the treatment of skin diseases associated with hyper-pigmentation after UV exposure and application in cosmetics for whitening and depigmentation.
|
28478573 |
2018 |
|
Dermatologic disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Trans-resveratrol (RSV) is a natural compound with several properties, such as the ability to inhibit the tyrosinase enzyme, with potential application as a skin-lightning agent and for the treatment of skin disorders associated with hyperpigmentation and melanogenesis.
|
29404955 |
2018 |
|
Dermatologic disorders
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The regulation of tyrosinase activity and reactive oxygen species is of great importance for the prevention of dermatological disorders in the fields of medicine and cosmetics.
|
29533643 |
2018 |
|
Dermatologic disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Tyrosinase is the rate-limiting enzyme for controlling the production of melanin in the human body, and overproduction of melanin can lead to a variety of skin disorders.
|
29067862 |
2018 |
|
Dermatologic disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
As a well-known copper-containing oxidase, tyrosinase has been anticipated to serve as the biomarker of skin diseases.
|
28891289 |
2017 |
|
Dermatologic disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Tyrosinase inhibition assays demonstrated that aliphatic KA dienols, the major degradation product under skin conditions, were more potent then KA itself.
|
28026947 |
2017 |
|
Dermatologic disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Overproduction and stimulation of tyrosinase result in increased melanogenesis of which several skin disorders such as freckles, spots, and hyperpigmentation appear as complications.
|
28872626 |
2017 |
|
Dermatologic disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Tyrosinase (TYR) is a key enzyme in melanin biosynthesis and its activity is an important biomarker for dermatological disorders, such as vitiligo, melanoma and actinic damages.
|
29126486 |
2017 |