TYR, tyrosinase, 7299

N. diseases: 281; N. variants: 121
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0877008
Disease: Enzyme inhibition disorder
Enzyme inhibition disorder
0.060 GeneticVariation phenotype BEFREE Total bioactive contents, antioxidant (phosphomolybdenum and metal chelating, DPPH, ABTS, FRAP and CUPRAC) and enzyme inhibition (cholinesterases, tyrosinase α-amylase, and α-glucosidase) potential were assessed utilizing in vitro bioassays. 31154083 2019
CUI: C0877008
Disease: Enzyme inhibition disorder
Enzyme inhibition disorder
0.060 AlteredExpression phenotype BEFREE Synthesis and structure-activity relationship of tyrosinase inhibiting novel bi-heterocyclic acetamides: Mechanistic insights through enzyme inhibition, kinetics and computational studies. 30772647 2019
CUI: C0877008
Disease: Enzyme inhibition disorder
Enzyme inhibition disorder
0.060 AlteredExpression phenotype BEFREE This review gives an overview of tyrosinase activity and describes tyrosinase-inhibiting thiosemicarbazones in terms of their structure-activity relationships, kinetics of enzyme inhibition and mechanism of action. 31015905 2019
CUI: C0877008
Disease: Enzyme inhibition disorder
Enzyme inhibition disorder
0.060 Biomarker phenotype BEFREE Synthesis of aryl pyrazole via Suzuki coupling reaction, in vitro mushroom tyrosinase enzyme inhibition assay and in silico comparative molecular docking analysis with Kojic acid. 29793142 2018
CUI: C0877008
Disease: Enzyme inhibition disorder
Enzyme inhibition disorder
0.060 AlteredExpression phenotype BEFREE Marked tyrosinase enzyme inhibition activity and antioxidant activity of both plant extracts might be due to polyphenols and flavonoids. 29453917 2018
CUI: C0877008
Disease: Enzyme inhibition disorder
Enzyme inhibition disorder
0.060 Biomarker phenotype BEFREE Furthermore, indicated an efficient antibacterial, lipoxygenase, and tyrosinase enzyme inhibition activities. 30142542 2018