UBE2L3, ubiquitin conjugating enzyme E2 L3, 7332

N. diseases: 56; N. variants: 39
Disease: Autoimmune Diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.140 GeneticVariation group GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.140 GeneticVariation group BEFREE The ubiquitin conjugating enzyme E2L3 (UBE2L3) gene is associated with susceptibility to many autoimmune diseases. 27094594 2016
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.140 GeneticVariation group BEFREE By accurately quantifying NF-κB translocation in primary human cells from healthy individuals stratified by rs140490 genotype, we observed that the autoimmune disease risk UBE2L3 genotype was correlated with basal NF-κB activation in unstimulated B cells and monocytes and regulated the sensitivity of NF-κB to CD40 stimulation in B cells and TNF stimulation in monocytes. 25640675 2015
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.140 GeneticVariation group BEFREE The autoimmune disease risk allele of UBE2L3 in African American patients with systemic lupus erythematosus: a recessive effect upon subphenotypes. 22045845 2012
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.140 GeneticVariation group BEFREE The results suggest that variants carried on the SLE-associated UBE2L3 risk haplotype influence autoimmunity by modulating UBCH7 expression. 22476155 2012
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.140 GeneticVariation group GWASDB Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. 21383967 2011